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Lumasiran
go.drugbank.com/drugs/DB15935ApprovedInvestigationalLumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1). … [L23554] This condition, caused by a deficiency in the enzyme alanine-glyoxylate aminotransferase, leads to an accumulation of oxalate, causing calcium crystal formation.
Lusutrombopag
go.drugbank.com/drugs/DB13125ApprovedInvestigationalThrombocytopenia, which indicates abnormally low levels of platelets, is a common complication related to chronic liver disease. … Lusutrombopag binds to the transmembrane domain of TPOR expressed on megakaryocytes, and causes the proliferation and differentiation of megakaryocytic progenitor cells from hematopoietic stem cells [FDA
Yellow fever vaccine
go.drugbank.com/drugs/DB10805ApprovedInvestigationalYellow fever vaccine prevents against Yellow Fever, a viral hemorrhagic disease caused by the transmission of a _flavivirus_ through the bite of an infected mosquito. … The World Health Organization recommends routine vaccination in countries where Yellow Fever is endemic, and for travellers going to endemic areas as proof of vaccination is often a requirement at border
Synonyms: Yellow fever virus live antigen, AAminopterin
go.drugbank.com/drugs/DB08878ApprovedWithdrawnAminopterin is an amino derivative of folic acid, which was once used as an antineoplastic agent in the treatment of pediatric leukemia. … Clinicians need to be aware of the characteristic teratologic effects of aminopterin and methotrexate.
Aloe vera leaf
go.drugbank.com/drugs/DB13906ApprovedInvestigationalThe active constituents of aloe vera include polysaccharides with protective effects on skin, as they exhibit antioxidant and anti-inflammatory properties [A32481]. … Aloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands.
Mixtures: Alcortin A, Alcortin ASynonyms: Lu hui ye, Lu hui (aloe vera)Pegaspargase
go.drugbank.com/drugs/DB00059ApprovedInvestigational[A103,A255912,L44667] Pegaspargase has the same mechanism of action as [L-asparaginase] derived from _Escherichia coli_, a previously developed enzyme used for the treatment of acute lymphoblastic … Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia
Categories: Compounds used in a research, industrial, or household settingProducts: ONCASPAR® 750 U/ML POLVO PARA SOLUCIÓN INYECTABLE, ONCASPAR POWDER FOR SOLUTION FOR INJECTION/INFUSION 750 U/MLDostarlimab
go.drugbank.com/drugs/DB15627ApprovedInvestigational[A234379] Agents acting on the PD-1 pathway, such as [nivolumab] and [pembrolizumab], facilitate endogenous immune-mediated anti-tumor activity and may therefore be used to treat a wide variety of cancers … In April 2021, dostarlimab was granted accelerated approval by the FDA - as GlaxoSmithKline's dostarlimab-gxly (Jemperli) - for the treatment of adult patients with recurrent or advanced mismatch repair
Diclofenamide
go.drugbank.com/drugs/DB01144ApprovedA carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
Categories: combinations of sulfonamidesBioallethrin
go.drugbank.com/drugs/DB13746ApprovedWithdrawnA mixture containing only S-forms of allethrin is referred to as esbioallethrin or S-bioallethrin. … A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin.
Categories: Compounds used in a research, industrial, or household settingTrimethaphan
go.drugbank.com/drugs/DB01116ApprovedInvestigationalA nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.