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Tigecycline
go.drugbank.com/drugs/DB00560ApprovedInvestigationalFood and Drug Administration (FDA) on June 17, 2005. … It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S.
Products: TIGLEX 50 MG, TIGECLIN® 50 MG VIALGemfibrozil
go.drugbank.com/drugs/DB01241ApprovedInvestigational[L8525] Gemfibrozil was granted FDA approval on 21 December 1981.[L8525]
International brands: Gen-FibroProducts: GEMITER 300 MG, HIDIL 600 TABLET 600 mgOsimertinib
go.drugbank.com/drugs/DB09330ApprovedInvestigationalIn contrast, third-generation inhibitors are specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease. … [A7927] More specifically, deletions around the LREA motif in exon 19 and exon 21 L858R point mutations are correlated with response to therapy.
Synonyms: N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamideProducts: TAGRISSO® 40 MG, TAGRISSO® 80 MG.Calcium lactate
go.drugbank.com/drugs/DB13231ApprovedVet approvedCalcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Mixtures: FOSFO KALSIYUM GRANULE, 200 G, Min-tran TabProducts: CALAC TABLET 300 MG, PHARMANIAGA CALCIUM TABLET 300 MGVinflunine
go.drugbank.com/drugs/DB11641ApprovedInvestigationalIn 2009, vinflunine was approved by the European Medicines Agency (EMA) as a second-line therapy of metastatic and advanced urothelial cancer after failure of platinum-based treatment [A32626]. … It was first described in 1998 at the Pierre Fabre research center in France.
Synonyms: 20',20'-difluoro-3',4'-dihydrovinorelbine, 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastineProducts: Javlor Concentrate for Solution for Infusion 25 mg/mLIcotinib
go.drugbank.com/drugs/DB11737InvestigationalIcotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) Icotinib was approved in China by the SFDA in June, 2011 and in January 2014, Beta Pharma, Inc
Synonyms: BPI-2009Sebelipase alfa
go.drugbank.com/drugs/DB11563ApprovedInvestigationalThe lysosomal acid lipase (LAL) enzyme is found in lysosomes and is primarily responsible for the metabolism of lipids, and its absence or deficiency results in the accumulation of lipids in various organs … This lipid accumulation can lead to end-organ damage in the form of liver dysfunction or malabsorption secondary to intestinal dysfunction.
Products: KANUMA® 2 MG/ML CONCENTRADO PARA SOLUCION PARA INFUSION.Cilazapril
go.drugbank.com/drugs/DB01340ApprovedInvestigationalIt is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States. … Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure. It belongs to the angiotensin-converting enzyme inhibitors (ACE inhibitors) class of drugs.
Mixtures: Inhibace plus 5 mg/12,5 mg - Filmtabletten, ACEPRIX PLUS 5 MG/12.5 MG FILM TABLET, 30 ADETCategories: Agents Acting on the Renin-Angiotensin SystemPiritramide
go.drugbank.com/drugs/DB12492ApprovedWithdrawnPiritramide is under investigation for the treatment of Colon Cancer and Minimal Residual Disease. Piritramide has been investigated for the supportive care of Pain, Postoperative and Postoperative Nausea and Vomiting.
Products: Dipidolor 7,5 mg/ml InjektionslösungEftrenonacog alfa
go.drugbank.com/drugs/DB11608ApprovedIt was first approved by the FDA in March 2014 and later approved by the EMA in May 2016. … Eftrenonacog alfa is a long-acting recombinant fusion protein used in the treatment of hemophilia B.
Products: ALPROLIX® 250 UI