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Displaying results 1551 - 1560 of 4004 in total
  1. Drug

    Formestane

    go.drugbank.com/drugs/DB08905
    ApprovedWithdrawn

    With the discovery of newer, non-steroidal and steroidal, aromatase inhibitors which were orally active and less expensive than formestane, formestane lost popularity.

  2. Drug

    Glembatumumab vedotin

    go.drugbank.com/drugs/DB05996
    Investigational

    A conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer.

  3. Drug

    Mupadolimab

    go.drugbank.com/drugs/DB16488
    Investigational

    NCT03454451 focused on advanced cancers (e.g., non-small cell lung cancer, renal cell cancer, colorectal cancer).

  4. Drug

    Prednisone

    go.drugbank.com/drugs/DB00635
    ApprovedInvestigationalVet approved

    [L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]

  5. Drug

    Prednisolone phosphate

    go.drugbank.com/drugs/DB14631
    ApprovedInvestigationalVet approved

    [A187463] Prednisolone phosphate was granted FDA Approval on 19 December 1973.[L14144]

  6. Target

    Osteocalcin

    go.drugbank.com/bio_entities/BE0000724
    TargetHumans

    Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (By similarity). … The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (PubMed:3019668, PubMed:6967872).

    Synonyms: Bone Gla protein
  7. Target

    Growth/differentiation factor 2

    go.drugbank.com/bio_entities/BE0010630
    TargetHumans

    Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG

    Synonyms: Bone morphogenetic protein 9
  8. Target

    Growth/differentiation factor 11

    go.drugbank.com/bio_entities/BE0010786
    TargetHumans

    Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterni...

    Synonyms: Bone morphogenetic protein 11
  9. Drug

    Tadalafil

    go.drugbank.com/drugs/DB00820
    ApprovedInvestigational

    Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy. It was first approved in 2003 by the FDA for use ...

  10. Drug

    Taurocholic acid

    go.drugbank.com/drugs/DB04348
    Approved

    The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagog...

    Mixtures: Lax-BO Tab