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Polysorbate 80
go.drugbank.com/drugs/DB11063ApprovedInvestigationalPolysorbate 80 is a hydrophilic nonionic surfactant. It is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops. … A substance that would not normally dissolve in a particular solution is able to dissolve with the use of a solubilizing agent.
Mixtures: i-Drops ARTIFICIAL TEARS, ENDURA® UDCategories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsLamivudine
go.drugbank.com/drugs/DB00709ApprovedInvestigationalIt is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). … A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring.
Mixtures: N/A, N/ACategories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingSAR445136
go.drugbank.com/drugs/DB17708InvestigationalSAR445136 is an investigational zinc finger nuclease gene-edited cell therapy. … It consists of autologous CD34+ hematopoietic stem precursor cells (HSPC) modified ex vivo by zinc finger nucleases (ZFN) that target the BCL11A gene erythroid-specific enhancer (ESE) to increase endogenous
Oxethazaine
go.drugbank.com/drugs/DB12532ApprovedWithdrawnOxetacaine, also called oxethazaince, is a potent surface analgesic with the molecular formula N, N-bis-(N-methyl-N-phenyl-t-butyl-acetamide)-beta-hydroxyethylamine that conserves its unionized form at … [L1113] It is also in the list of approved derivatives of herbal products by the EMA.[L2816]
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsNifurtimox
go.drugbank.com/drugs/DB11820ApprovedInvestigationalChagas disease, caused by a parasite known as Trypanosoma cruzi (T.cruzi), is a vector-transmitted disease affecting animals and humans in the Americas. … If Chagas disease is left untreated, life-threatening sequelae may result.[L15366] Nifurtimox, developed by Bayer, is a nitrofuran antiprotozoal drug used in the treatment of Chagas disease.
Categories: Heterocyclic Compounds, 1-RingGlecaprevir
go.drugbank.com/drugs/DB13879ApprovedInvestigationalGlecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. … In combination with [DB13878], glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors.
Mixtures: MAVIRET® 100/40 MG TABLETAS RECUBIERTASCategories: P-glycoprotein inhibitors, P-glycoprotein substratesInfigratinib
go.drugbank.com/drugs/DB11886ApprovedInvestigationalWithdrawnInfigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. … [A198963] Infitratinib is a pan-FGFR inhibitor, as it is an ATP-competitive inhibitor of all four FGFR receptor subtypes.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsTolfenamic acid
go.drugbank.com/drugs/DB09216ApprovedIt is used in the UK as a treatment for migraine under the name of Clotam.[L1292] In the US, it presents a Status class I by the FDA. … Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent.
Categories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSProducts: TOLFEDINE 4% W/V SOLUTION FOR INJECTION FOR DOGS AND CATS, Tolfine Solution for Injection 4.0% W/VLevothyroxine
go.drugbank.com/drugs/DB00451ApprovedInvestigationaldeiodination (by type I or type II 5′-deiodinases)[A179941] into its active metabolite T<sub>3</sub>. … Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland.
Synonyms: O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine, 3,5,3',5'-Tetraiodo-L-thyronineMixtures: L THYROX JOD HEXAL 50/150, L THYROX JOD HEXAL 50/150Calaspargase pegol
go.drugbank.com/drugs/DB14730ApprovedInvestigationalCalaspargase pegol, also known as _asparlas_, is an asparagine specific enzyme which is indicated as a part of a multi-agent chemotherapy regimen for the treatment of ALL [L4890]. … SC) linker to create a stable molecule which increases the half-life and decreases the dosing frequency [FDA label], [A40270].
Categories: L-asparaginase containing drugs, Compounds used in a research, industrial, or household setting