Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as... It is used in the UK as a treatment for migraine under the name of Clotam.
- Mechanism
- Curator reviewed · 2 references
Tolfenamic acid inhibits the biosynthesis of prostaglandins, and it also presents inhibitory actions on the prostaglandin receptors. As commonly thought, the mechanism of action of tolfenamic acid is based on the major mechanism of NSAIDs which consists of the inhibition of COX-1 and COX-2 pathways to inhibit prostaglandin secretion and action and thus, to exert its anti-inflammatory and pain-blocking action. Nonetheless, some report currently indicates that tolfenamic acid inhibits leukotriene B4 chemotaxis of human polymorphonuclear leukocytes leading to an inhibition of even 25% of the chemotactic response. This activity is a not ligand specific additional anti-inflammatory mechanism of tolfenamic acid.
- Primary indication
- In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults.Curator reviewed
- Formula / weight
- C14H12ClNO2 · 261.704 g/mol (avg)
Resolves to
YEZNLOUZAIOMLT-UHFFFAOYSA-NSMILESCC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=OWhat you can answer from here — as of April 23, 2025
Which drugs share a target with Tolfenamic acid, and which of those have an active Phase 3 trial?
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