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Bulevirtide
go.drugbank.com/drugs/DB15248ApprovedInvestigationalHepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality. … [L30215] In the USA, bulevirtide has been granted Orphan Drug Designation and Breakthrough Therapy Designation.
Salts: Bulevirtide acetateCategories: Amino Acids, Peptides, and ProteinsLefamulin
go.drugbank.com/drugs/DB12825Approved[A183206] Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August 2019.
Salts: Lefamulin acetateCategories: AcetatesNafarelin
go.drugbank.com/drugs/DB00666ApprovedInvestigationalNafarelin has been used in the treatments of central precocious puberty and endometriosis.
Salts: Nafarelin acetateCategories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsDifelikefalin
go.drugbank.com/drugs/DB11938ApprovedInvestigational[L36420,L36395] Difelikefalin was later approved by the EMA in April 2022 for the same indication.[L41665] … [A237620] Options for therapy are limited - with no FDA-approved treatments, off-label [gabapentin] was the most evidence-based and widely available treatment.
Salts: Difelikefalin acetateFluorometholone
go.drugbank.com/drugs/DB00324ApprovedInvestigationalA glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders.
Salts: Fluorometholone acetateCategories: fluorometholone and mydriatics, fluorometholone and antibioticsIcatibant
go.drugbank.com/drugs/DB06196ApprovedInvestigational[A4017,A263046] Icatibant was approved by the FDA on August 25, 2011, and by the EMA in 2008 as a treatment for hereditary angioedema. … It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than earlier B<sub>2</sub> receptors antagonists, thus representing a new class of medication.
Salts: Icatibant acetateCategories: Amino Acids, Peptides, and Proteins, Intercellular Signaling Peptides and ProteinsLinaclotide
go.drugbank.com/drugs/DB08890ApprovedInvestigational[A260271] It gained EMA and Health Canada approval on November 26, 2012 [L47216] and December 3, 2013,[L47221] respectively. … Linaclotide is a synthetic 14-amino acid cyclic peptide [A260271] and first-in-class guanylate cyclase-C (G-CC) agonist.
Salts: Linaclotide acetateCategories: Alimentary Tract and Metabolism, Amino Acids, Peptides, and ProteinsZiconotide
go.drugbank.com/drugs/DB06283ApprovedInvestigational[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be
Salts: Ziconotide acetateCategories: Fluids and Secretions, Calcium-Regulating Hormones and AgentsPeginesatide
go.drugbank.com/drugs/DB08894ApprovedWithdrawnThe polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. … Peginesatide consists of two 21-amino acid chains that are covalently bonded by a linker derived from iminodiacetic acid and β-alanine. FDA approved March 27, 2012.
Salts: Peginesatide acetateCategories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsMotixafortide
go.drugbank.com/drugs/DB14939ApprovedInvestigational[L48116] When administered alongside [filgrastim], another agent used to aid in stem cell collection, motixafortide enabled the collection of an adequate number of stem cells in ~92% of patients within … is commonly employed in the context of hematologic cancers - high-dose chemotherapy regimens destroy cancerous blood cells, which are then replaced via infusion of the patient's own stem cells (i.e. an
Salts: Motixafortide acetateCategories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating Agents