Fluorometholone is an ophthalmic corticosteroid used for the relief of inflammation located in both the palpebral and bulbar conjunctiva, the cornea, and the anterior segment of the globe of the eye. A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye.
- Mechanism
- Curator reviewed
There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Their primary target is the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.
- Primary indication
- For the ophthalmic treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.Curator reviewed · 6 structured indications
- Formula / weight
- C22H29FO4 · 376.4617 g/mol (avg)
- First approval
- Canada, 1998 · United States, 1972
- Code names
- NSC 33001 · U 17323
- Brand names
Resolves to
FAOZLTXFLGPHNG-KNAQIMQKSA-NSMILES[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Fluorometholone, and which of those have an active Phase 3 trial?
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