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Displaying results 1591 - 1600 of 10000 in total
  1. Drug

    Lurbinectedin

    go.drugbank.com/drugs/DB12674
    ApprovedInvestigational

    the substitution of the tetrahydroisoquinoline with a tetrahydro β‐carboline that results in increased antitumour activity of lurbinectedin as compared to its predecessor. … Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma,[A214325] chronic lymphocytic leukemia (CLL),[A214328] breast cancer,

    Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitors
  2. Drug

    Difamilast

    go.drugbank.com/drugs/DB14987
    ApprovedInvestigational

    [L56052, A275420] This skin disease occurs most frequently in children and can have an onset as early as within the first 2 years of life. … Atopic dermatitis is a chronic and fluctuating pruritic inflammatory skin condition characterized by pruritic eczema and is also marked by exacerbations and remissions.

    Synonyms: 地法米司特Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inducers
  3. Drug

    Octocrylene

    go.drugbank.com/drugs/DB09535
    Approved

    Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. … What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure.

    Mixtures: Thermal S Uv SPF 20, Ponte Vedra Inn SPF 50 C/S SunscreenProducts: Panama Jack SPF 4, Panama Jack SPF 4 Dark Tanning Oil
  4. Drug

    Pentostatin

    go.drugbank.com/drugs/DB00552
    ApprovedInvestigational

    A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. … It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

    Categories: Heterocyclic Compounds, 1-Ring, Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index
  5. Drug

    LetibotulinumtoxinA

    go.drugbank.com/drugs/DB16820
    Approved

    [L42330] LetibotulinumtoxinA has been a market-leading cosmetic product in South Korea for a number of years and was subsequently approved in the European Union. … [L42330] It is a 900 kDa multimeric complex comprising a 150 kDa toxin, a 130 kDa non-toxic non-haemagglutinating protein, and various other haemagglutinins.

    Synonyms: BoNT/A-DSCategories: Botulinum Toxins, Type A
  6. Drug

    Phenprocoumon

    go.drugbank.com/drugs/DB00946
    ApprovedInvestigationalWithdrawn

    Coumarin derivative that acts as a long-acting oral anticoagulant.

    Synonyms: 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one, 3-(1-Phenylpropyl)-4-hydroxycoumarinCategories: 4-Hydroxycoumarins, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index
  7. Drug

    Dicoumarol

    go.drugbank.com/drugs/DB00266
    Approved

    Dicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. … In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.

    Synonyms: 3,3'-methylenebis(4-hydroxy-2H-1-benzopyran-2-one), bis(4-hydroxycoumarin-3-yl)methaneCategories: 4-Hydroxycoumarins, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index
  8. Drug

    Thrombomodulin Alfa

    go.drugbank.com/drugs/DB05777
    Approved

    Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). … It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular

  9. Drug

    Palbociclib

    go.drugbank.com/drugs/DB09073
    ApprovedInvestigational

    Palbociclib is a piperazine pyridopyrimidine[A176792] that acts in the cell cycle machinery. … It is a second generation cyclin-dependent kinase inhibitor[A176798] selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties.

    Synonyms: 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one, 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-oneMixtures: REAMPLA®, REAMPLA®
  10. Drug

    D-glucose

    go.drugbank.com/drugs/DB01914
    ApprovedInvestigationalVet approved

    L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. … Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants.

    Synonyms: D-glucose, D(+)-GlucoseSalts: D-glucose monohydrate