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Gadobenic acid
go.drugbank.com/drugs/DB00743ApprovedInvestigational[A263086] It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity. … Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver.
Categories: Compounds used in a research, industrial, or household settingProducts: MultiHance 0,5 M Injektionslösung, MULTIHANCE TEK DOZLUK IV ENJEKSIYONLUK COZELTI ICEREN FLAKON, 5 MLGlycyrrhizic acid
go.drugbank.com/drugs/DB13751ApprovedInvestigationalWhen extracted from the plant, it can be obtained in the form of ammonium glycyrrhizin and mono-ammonium glycyrrhizin. … [A33062] From January 2014, glycyrrhizic acid as part of the licorice extract was approved by the FDA as an existing food sweetener.
Zonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigationalZonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures. … [L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: Benzo[d]isoxazol-3-yl-methanesulfonamide, 1,2-Benzisoxazole-3-methanesulfonamideCarbimazole
go.drugbank.com/drugs/DB00389ApprovedAn imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
Synonyms: Ethyl 3-methyl-2-thioimidazoline-1-carboxylateCategories: Heterocyclic Compounds, 1-RingSER-287
go.drugbank.com/drugs/DB18204InvestigationalSER-287 comprises healthy microbiome-derived Gram positive bacterial spores.
LTI-03
go.drugbank.com/drugs/DB18491InvestigationalLTI-03 is a caveolin-1 Scaffolding Domain 7-Mer
Synonyms: L-threonine, l-phenylalanyl-l-threonyl-l-threonyl-l-phenylalanyl-l-threonyl-l-valyl-Acipimox
go.drugbank.com/drugs/DB09055ApprovedInvestigationalFlushing can be reduced by taking aspirin 20-30 min before taking Acipimox. High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout. … Acipimox is a niacin derivative used as a hypolipidemic agent.
Categories: Heterocyclic Compounds, 1-RingDitiocarb zinc
go.drugbank.com/drugs/DB14193ApprovedSensitivity to ditiocarb zinc may be identified with a clinical patch test. … Ditiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and zinc. It also a dermatological sensitizer and allergen.
Categories: Cytochrome P-450 CYP2A6 Inhibitors, Cytochrome P-450 CYP2E1 InhibitorsSynonyms: Zinc N,N-diethyldithiocarbamate, Zinc, bis(diethylcarbamodithioato-S,S')-Vilobelimab
go.drugbank.com/drugs/DB16416ApprovedInvestigational[L45839] In April 2023, the FDA issued an emergency use authorization (EUA) for vilobelimab for the treatment of COVID-19 in hospitalized adults requiring mechanical ventilation or artificial life support … Vilobelimab is a chimeric monoclonal immunoglobulin G4 (IgG4) antibody that binds to the soluble form of human C5a with high affinity.
Synonyms: IFX-1Pacritinib
go.drugbank.com/drugs/DB11697ApprovedInvestigational[L40793] The underlying cause of primary MF is unknown, but secondary MF can arise in patients with a history of polycythemia vera or essential thrombocythemia. … [L40793] While some patients may remain asymptomatic, typical symptoms of MF arise from abnormalities in blood cell production and may therefore include various cytopenias, infections, splenomegaly, and
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP1A2 Inducers