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Displaying results 1661 - 1670 of 10000 in total
  1. Target

    Vascular cell adhesion protein 1

    go.drugbank.com/bio_entities/BE0001114
    TargetHumans

    Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothe...

    Synonyms: INCAM-100
  2. Drug

    Mifepristone

    go.drugbank.com/drugs/DB00834
    ApprovedInvestigational

    Mifepristone is a progestational and glucocorticoid hormone antagonist. … As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome.

    Products: MIFEPRISTONA 200 MG, MIFEPRISTONE 200 MG
  3. Drug

    Favipiravir

    go.drugbank.com/drugs/DB12466
    ApprovedInvestigational

    Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza. … [A191688,A191772,A191775] Not only does favipiravir inhibit replication of influenza A and B, but the drug has shown promise in the treatment of avian influenza, and may be an alternative option for

    Products: L-VIR, KOVİPİR 200 MG FİLM KAPLI TABLET, 40 ADET
  4. Drug

    Ixabepilone

    go.drugbank.com/drugs/DB04845
    ApprovedInvestigational

    Ixabepilone is a semisynthetic analogue of epothilone B. It has a lactone–lactam modification that minimizes susceptibility to esterase degradation. … Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: IXEMPRA FOR INJECTION 15 MG, IXEMPRA (FOR INJECTION 15 MG)
  5. Drug

    Carbimazole

    go.drugbank.com/drugs/DB00389
    Approved

    An imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.

    Products: CARBIMAZOL 1A PHARMA 5MG, CAMAZOL TABLET 5 mg
  6. Drug

    Rimonabant

    go.drugbank.com/drugs/DB06155
    ApprovedWithdrawn

    This decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression.

    Products: ACOMPLIA ® COMPRIMIDOS RECUBIERTOS20 MG
  7. Drug

    Dronedarone

    go.drugbank.com/drugs/DB04855
    ApprovedInvestigational

    A safety concern for the risk of drug-induced hepatocellular injury has been issued following marketing of dronedarone.[L8800] … Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management.

    Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: MULTAQ (400 MG), MULTAQ 400 MG FILM-COATED TABLETS
  8. Drug

    Butenafine

    go.drugbank.com/drugs/DB01091
    Approved

    Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine's mechanism of action is believed to involve the synthesis inhibition of sterols.

    Products: BUTAFLY % 1 LOSYON ,10 ML, Tinactin Once-A-day Cream
  9. Drug

    Ribociclib

    go.drugbank.com/drugs/DB11730
    ApprovedInvestigational

    Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6).

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: KISQALI (200 MG), KISQALI 200 MG TABLETAS RECUBIERTAS
  10. Drug

    Medazepam

    go.drugbank.com/drugs/DB13437
    Investigational

    Mixtures: TRANKO-BUSKAS 10 MG + 10 MG KAPLI TABLET, 40 ADET, TRANKO-BUSKAS 10 MG + 10 MG KAPLI TABLET, 20 ADETProducts: NOBRAL 10 MG KAPSÜL, 20 ADET, NOBRAL 10 MG KAPSÜL, 250 ADET