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Ethotoin
go.drugbank.com/drugs/DB00754ApprovedEthotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A InducersSynonyms: 1-ethyl-2,5-dioxo-4-phenylimidazolidine, (±)-3-ethyl-5-phenylhydantoinCefonicid
go.drugbank.com/drugs/DB01328ApprovedA second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. … It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-8-oxo-3-({[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid1-Naphthylamine-5-sulfonic acid
go.drugbank.com/drugs/DB07176ExperimentalSynonyms: 1-Amino-5-sulfonaphthalene, 1-Amino-5-naphthalenesufonic acidOfloxacin
go.drugbank.com/drugs/DB01165ApprovedInvestigationalA synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Categories: 4-Quinolones, Heterocyclic Compounds, 2-RingSynonyms: 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acidSparfloxacin
go.drugbank.com/drugs/DB01208ApprovedWithdrawnSparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. … DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Categories: 4-Quinolones, P-glycoprotein substratesSynonyms: cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid1-Deoxy-Ribofuranose-5'-Phosphate
go.drugbank.com/drugs/DB03936ExperimentalSynonyms: 1-Deoxy-Ribofuranose-5'-PhosphateAKV-9
go.drugbank.com/drugs/DB18061ExperimentalSynonyms: 5-((S)-1-(3,5-bis(trifluoromethyl)phenoxy)ethyl)-3-hydroxycyclohex-2-en-1-one, 1,3-Cyclohexanedione, 5-[(1S)-1-[3,5-bis(trifluoromethyl)phenoxy]ethyl]-Thymidine
go.drugbank.com/drugs/DB04485ApprovedInvestigational[A274683] While it lacks significant anti-tumor activity on its own,[A274688] it has been extensively investigated for nearly a decade as a biochemical modulator to enhance the efficacy and reduce the … toxicity of established anti-metabolite chemotherapeutic agents, such as 5-Fluorouracil (FU), Methotrexate (MTX), and Cytosine arabinoside (ara-C).
Categories: Heterocyclic Compounds, 1-RingSynonyms: MT-1621 COMPONENT 2'-DEOXYTHYMIDINE, 1-(2-Deoxy-?-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedioneChlorthalidone
go.drugbank.com/drugs/DB00310ApprovedInvestigationalChlorthalidone has been shown to have a number of pleiotropic effects that differentiate it from other diuretics such as [DB00999]. … These pathways may play a role in chlorthalidone's cardiovascular risk reduction effects.[A176330]
Mixtures: ATENOLOLO CLORTALIDONE EG, ATENOLOLO CLORTALIDONE EGCategories: Heterocyclic Compounds, 2-RingMelatonin
go.drugbank.com/drugs/DB01065ApprovedInvestigationalNutraceuticalVet approvedMelatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. … The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence the name), that is located in the center of the brain (rostro-dorsal to the superior colliculus
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesSynonyms: 5-methoxy-N-acetyl tryptamine, 5-methoxy-N-acetyltryptamine