Ofloxacin is an antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract. A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
- Mechanism
- Curator reviewed
Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.
- Primary indication
- For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.Curator reviewed · 20 structured indications
- Formula / weight
- C18H20FN3O4 · 361.3675 g/mol (avg)
- First approval
- Canada, 1999 · United States, 1990
- Also known as
- OFLX
- Code names
- DL-8280 · HOE-280
- Brand names
Resolves to
GSDSWSVVBLHKDQ-UHFFFAOYSA-NSMILESCC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1What you can answer from here — as of September 23, 2026
Which drugs share a target with Ofloxacin, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account