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Dezocine
go.drugbank.com/drugs/DB01209ApprovedInvestigationalDezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: (−)-13β-amino-5,6,7,8,9,10,11α,12-octahydro-5α-methyl-5,11-methanobenzocyclodecen-3-olDuloxetine
go.drugbank.com/drugs/DB00476ApprovedInvestigational[L6454] It has since received approval for a variety of indications including the treatment of neuropathic pain, Generalized Anxiety disorder, osteoarthritis, and stress incontinence. … Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more.
Categories: Combined Inhibitors of Serotonin/Norepinephrine Reuptake, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: Ag-duloxetine, DU-TWO ® 30 MGRiociguat
go.drugbank.com/drugs/DB08931ApprovedInvestigationalthe treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurrent PH (pulmonary hypertension) after pulmonary endarterectomy in WHO FC II or III. … Treatment with riociguat costs USD $7,500 for 30 days of treatment.
Products: Adempas 2 mg film-coated tablet, PULLMOGUAT® 2 MG TABLETA RECUBIERTAEdaravone
go.drugbank.com/drugs/DB12243ApprovedInvestigational[A19140,L44007,A254257] The intravenous formulation of edaravone was first approved in Japan in 2001 for the treatment of acute ischemic stroke. … [L44007] The oral suspension formulation of edaravone was approved by the FDA in May 2022 and by Health Canada in November 2022.
Categories: Compounds used in a research, industrial, or household settingZuclopenthixol
go.drugbank.com/drugs/DB01624ApprovedInvestigationalZuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. … Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound belongs to the thioxanthenes.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: CLOPIXOL 10 MG, CLOPIXOL DEPOT INJECTION 200 mg/mlPolycarbophil
go.drugbank.com/drugs/DB09311ApprovedWithdrawnThis drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea. … The material possesses exceptionally high water-binding capacity. is not absorbed, does not interfere with the activity of digestive enzymes or intestinal absorption, possesses satisfactory stability,
Categories: Compounds used in a research, industrial, or household settingCaroxazone
go.drugbank.com/drugs/DB09254ApprovedWithdrawnIt is a reversible monoamine oxidase inhibitor (MAOI) of both A and B monoamine oxidase subtypes. However, it presents a five-fold preference for the MAO-B subtype.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProgesterone
go.drugbank.com/drugs/DB00396ApprovedInvestigationalVet approvedPlease see [Medroxyprogesterone acetate], [Megestrol acetate], [Dydrogesterone] and [Hydroxyprogesterone] entries for information on various other forms of progesterone. … A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss [A175609].
Categories: Sex Hormones and Modulators of the Genital SystemProducts: JARIT® 100 MG, JARIT® 200 MGEfgartigimod alfa
go.drugbank.com/drugs/DB15270ApprovedInvestigational[A243759] The production of IgG autoantibodies against acetylcholine receptors (AChRs) is one of the more common pathophysiological mechanisms behind MG, and results in the destruction of these receptors … [A243759,A243784] Efgartigimod alfa is a first-in-class[L39501] antagonist of the neonatal Fc receptor (FcRn) used in the treatment of MG.
Categories: Human Immunoglobulin GMianserin
go.drugbank.com/drugs/DB06148ApprovedWithdrawnMianserin was previously available internationally, however in most markets it has been phased out in favour of [mirtazapine].
Categories: Combined Inhibitors of Serotonin/Norepinephrine Reuptake, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: MIANSERIN-NEURAX 10 MG, MIANSERIN-NEURAX 30 MG