Mianserin

DB06148ApprovedWithdrawnSmall molecule

Mianserin is a tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety. Mianserin was previously available internationally, however in most markets it has been phased out in favour of mirtazapine.

Chemical structure of Mianserin
Mechanism
Curator reviewed
Primary indication
For the treatment of depression.Curator reviewed · 1 structured indication
Formula / weight
C18H20N2 · 264.3648 g/mol (avg)

Resolves to

Compound
UNII250PJI13LMCAS24219-97-4ChEMBLCHEMBL6437ChEBI51137PubChem4184
Clinical / RWD
RxNorm6929ATCN06AX03PharmGKBPA134687937
Structure
InChIKeyUEQUQVLFIPOEMF-UHFFFAOYSA-NSMILESCN1CCN2C(C1)C1=CC=CC=C1CC1=CC=CC=C21
Targets
P08913ADRA2AP28223HTR2AP28335HTR2CP35367HRH1P23975SLC6A2P31645SLC6A4Q9H3N8HRH4P08908HTR1A+10 more

What you can answer from here — as of September 23, 2026

20Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1,561Drug interactionsStructured to mechanism, not free text
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5Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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35Marketed productsAcross 6 countries and 11 labellers
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1ATC codeIncluding every combination product, plus 32 drug categories
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69+ReferencesStructured and connected to the statements they support
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