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Sibeprenlimab
go.drugbank.com/drugs/DB18919ApprovedInvestigational[L54633] On November 25, 2025, sibeprenlimab was granted accelerated approval by the FDA to reduce proteinuria in adults with primary IgAN at risk for disease progression.[L54628]
Methyl nicotinate
go.drugbank.com/drugs/DB13882ApprovedMethyl nicotinate is the methyl ester of [DB00627] that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. … For veterinary purposes, methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains [F64].
Mixtures: Arthricare for Women Nighttime, Arthricare for Women Multi-actionReserpine
go.drugbank.com/drugs/DB00206ApprovedWithdrawnThe FDA withdrew its approval for the use of all oral dosage form drug products containing more than 1 mg of reserpine.[L43942] … It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
Categories: Antihypertensive Agents Indicated for Hypertension, P-glycoprotein inducersAlendronic acid
go.drugbank.com/drugs/DB00630ApprovedInvestigationalAlendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111].
Categories: Drugs for Treatment of Bone DiseasesProducts: Ran-alendronate, Van-alendronateBenzydamine
go.drugbank.com/drugs/DB09084ApprovedInvestigationalIt is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system. … drug (NSAID), it has various physicochemical properties and pharmacologic activities that are different from those of traditional aspirin-like NSAIDs but facilitate benzydamine's mechanism of action as an
Categories: Topical Products for Joint and Muscular Pain, Antiinflammatory Products for Vaginal AdministrationProducts: TANTUM VERDE P, Biramine 3 mg/ml Spray zur Anwendung in der Mundhöhle, Lösung2,2'-Dibenzothiazyl disulfide
go.drugbank.com/drugs/DB14201ApprovedSensitivity to 2,2'-Dibenzothiazyl disulfide may be identified with a clinical patch test. … 2,2'-Dibenzothiazyl disulfide is an accelerator used in the processing process for natural and synthetic rubber and plastic regeneration. It is also a known allergen and dermatological sensitizer.
Hydroxyzine
go.drugbank.com/drugs/DB00557ApprovedInvestigational[L9677] The active metabolite of hydroxyzine, [cetirizine], is also available as an active ingredient in allergic medications, and is responsible for much of its hydroxyzine's antihistaminic effect. … [A189753] Hydroxyzine is also used for generalized anxiety disorder, tension caused by psychoneurosis, and other conditions with manifestations of anxiety.[L9677]
Categories: Histamine Receptor Antagonists, P-glycoprotein substratesSiponimod
go.drugbank.com/drugs/DB12371ApprovedInvestigationalSiponimod, also known as _Mayzent_, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). … Symptoms may include but are not limited to fatigue, gait changes, bowel or bladder dysfunction, abnormal muscle twitching, vision disturbance, and depressing or mood swings.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesAmisulpride
go.drugbank.com/drugs/DB06288ApprovedInvestigational[L32764] Amisulpride is also used as an antiemetic agent. … [A6752, L32764] Oral tablets of amisulpride is used in European countries as a treatment for acute and chronic schizophrenic disorders, as well as secondary negative symptoms in mental health disorders
Categories: P-glycoprotein substrates, Dopamine D2 Receptor AntagonistsDimethicone 410
go.drugbank.com/drugs/DB14005Approved[L1769] It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%. … [L2162] The name dimethicone has a lot of nomenclature inconsistencies as it is used to refer to common names, generic names, trade names or even for the listing of mixtures.