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Displaying results 171 - 180 of 10000 in total
  1. Drug

    Hydralazine

    go.drugbank.com/drugs/DB01275
    ApprovedInvestigational

    Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. … [A186820,L8782,L8785] Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications.

    Mixtures: Hydralazine HCl and Hydrochlorothiazide, Hydralazine HCl and HydrochlorothiazideCategories: hydralazine and diuretics, Hydrazinophthalazine Derivatives and Diuretics
  2. Drug

    Olanzapine

    go.drugbank.com/drugs/DB00334
    ApprovedInvestigational

    [A177011] Olanzapine was discovered by scientists at Eli Lilly and approved to be marketed in the US in 1996.[T548] … The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to

    Mixtures: TARGET 12MG /25 MG KAPSUL, 90 ADET, TARGET 12MG /50 MG KAPSUL, 90 ADETCategories: olanzapine and samidorphan, Diazepines, Oxazepines, Thiazepines and Oxepines
  3. Drug

    Leflunomide

    go.drugbank.com/drugs/DB01097
    ApprovedInvestigational

    Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. … Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous.

    Categories: Leflunomide and metabolite, Antineoplastic and Immunomodulating AgentsSynonyms: 4-ISOXAZOLECARBOXAMIDE, 5-METHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)-, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
  4. Drug

    Methotrimeprazine

    go.drugbank.com/drugs/DB01403
    Approved

    A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine.

    Categories: Analgesics, Non-Narcotic, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: (-)-(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
  5. Drug

    Zuclopenthixol

    go.drugbank.com/drugs/DB01624
    ApprovedInvestigational

    It is known that zuclopenthixol is metabolized by Cytochrome P450 2D6. Zuclopenthixol was approved for use in Canada in 2011, but is not approved for use in the United States. … Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: CIATYL Z 10MG, CLOPIXOL 10MG
  6. Drug

    RWJ-800088

    go.drugbank.com/drugs/DB18693
    Investigational

    RWJ-800088 is a synthetic PEGylated thrombopoietin (TPO) mimetic (TPOm) peptide with no sequence homology to endogenous TPO.

    Categories: Amino Acids, Peptides, and ProteinsSynonyms: a synthetic PEGylated thrombopoietin (TPO) mimetic (TPOm) peptide with no sequence homology to endogenous, -METHOXY-, 1,1'-DIETHER WITH N2,N6-BIS(N-(3-HYDROXY-1-OXOPROPYL)-L-ISOLEUCYL-L-.ALPHA.
  7. Drug

    Codeine

    go.drugbank.com/drugs/DB00318
    ApprovedIllicitInvestigational

    Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory … The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities.

    Mixtures: TALVOSILEN 500/20MG, A & C Tablets With Codeine 15mgCategories: Cough and Cold Preparations, codeine and ibuprofen
  8. Drug

    Telitacicept

    go.drugbank.com/drugs/DB18312
    Investigational

    Synonyms: (L120>A,L121>E,G123>A,A216>S,P217>S)-TACI (TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY PROTEIN TNFRSF13B) HUMAN EXTRACELLULAR DOMAIN FRAGMENT (13-118)-PEPTIDECategories: Amino Acids, Peptides, and Proteins
  9. Drug

    Doxorubicin

    go.drugbank.com/drugs/DB00997
    ApprovedInvestigational

    [A257614] Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin … ’s and Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers.

    Categories: Anthracyclines and Related Substances, Antineoplastic and Immunomodulating AgentsProducts: A.D. Mycin injection 2mg/ml, ADRIMEDAC 10MG (2MG/ML)
  10. Drug

    Thioridazine

    go.drugbank.com/drugs/DB00679
    ApprovedWithdrawn

    Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618). … A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: 3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine, 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine