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Displaying results 1801 - 1810 of 10000 in total
  1. Pathway

    Drospirenone Action Pathway

    smpdb.ca/view/SMP0126538
    Drug action

    This helps to oppose the effects of naturally occurring androgens, inhibiting the binding of dihydrotestosterone (DHT) to its receptor, and preventing androgen synthesis in the ovaries, helping to treat

    Drugs: NADH · ATP · Progesterone · Testosterone · Estrone · Potassium cation +9 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1, Androgen receptor
  2. Pathway

    Dienogest Action Pathway

    smpdb.ca/view/SMP0126541
    Drug action

    Dienogest acts by binding as an agonist to the progesterone receptor with weak affinity but high specificity. … Also, since this drug is an agonist of the androgen receptor, it helps to improve androgenic symptoms like acne and hirsutism. This drug is administered as an oral tablet.

    Drugs: NADH · ATP · Progesterone · Testosterone · Estrone · Potassium cation +9 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1, Androgen receptor
  3. Drug

    Torasemide

    go.drugbank.com/drugs/DB00214
    ApprovedInvestigational

    Torasemide is a high-ceiling loop diuretic.[A174463] Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. … [A319] Torasemide was first approved for clinical use by the FDA in 1993.[L5257]

  4. Drug

    Maralixibat

    go.drugbank.com/drugs/DB16226
    ApprovedInvestigational

    Maralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor, like [odevixibat]. … with Alagille syndrome:[L43547] it was granted marketing authorization in Europe on 13 December 2022.

  5. Drug

    N-acetyltyrosine

    go.drugbank.com/drugs/DB11102
    ApprovedInvestigational

    It is typically administered as a source of nutritional support where oral nutrition is inadequate or cannot be tolerated. … N-acetyltyrosine, also referred to as N-acetyl-L-tyrosine, is used in place of as a tyrosine precursor. [DB00135] is a non-essential amino acid with a polar side group.

    Mixtures: Aminosyn II in Dextrose, Aminosyn II in Dextrose
  6. Drug

    Cholecystokinin

    go.drugbank.com/drugs/DB08862
    ApprovedInvestigationalWithdrawn

    Recent studies have suggested that cholecystokinin also plays a major role in inducing drug tolerance to opioids such as morphine and heroin, and is partially implicated in experiences of pain hypersensitivity … Normally, it is an endogenous hormone but is available commercially for diagnostic processes and replacement in pancreatic insufficiency [L1646, L1647, L1648]. in the octapeptide form.

  7. Target

    Kainate receptors

    go.drugbank.com/bio_entities/BE0009793
    TargetHumans

    The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist … Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid.

    Polypeptides: Glutamate receptor ionotropic, kainate 1, Glutamate receptor ionotropic, kainate 2Synonyms: Glutamate receptor KA-1, Glutamate receptor KA-2
  8. Drug

    Dimethicone 410

    go.drugbank.com/drugs/DB14005
    Approved

    Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products.[A32462] It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. … [L1769] It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%.

  9. Drug

    Galsulfase

    go.drugbank.com/drugs/DB01279
    ApprovedInvestigational

    Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family … Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD.

  10. Drug

    Colestipol

    go.drugbank.com/drugs/DB00375
    Approved

    , colestipol is still generally only employed as an adjunct therapy and the relatively physical nature of its pharmacological activity sometimes limits its usefulness. … [FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia

    Categories: Compounds used in a research, industrial, or household setting