Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms. Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone.
- Mechanism
- Curator reviewed
Estrogens enter the cells of responsive tissues (e.g. female organs, breasts, hypothalamus, pituitary) where they interact with estrogen receptors. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) release from the anterior pituitary.
- Primary indication
- For management of perimenopausal and postmenopausal symptoms.Curator reviewed · 1 structured indication
- Formula / weight
- C18H22O2 · 270.3661 g/mol (avg)
- First approval
- Canada, 2015
- Also known as
- Follicular hormone · Folliculin · Oestrone
- Code names
- WAY 164397
- Brand names
Resolves to
DNXHEGUUPJUMQT-CBZIJGRNSA-NSMILES[H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3What you can answer from here — as of September 23, 2026
Which drugs share a target with Estrone, and which of those have an active Phase 3 trial?
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