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Sotorasib
go.drugbank.com/drugs/DB15569ApprovedInvestigationalSotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen. … [A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer.[L34288] This mutation makes up >50% of all KRAS mutations.
Products: LUMAKRAS 120 MG FİLM KAPLI TABLET, 240 ADETQueuine
go.drugbank.com/drugs/DB14732ExperimentalNutraceuticalQueuine is a derivative of [7-Deazaguanine]. Bacteria possess the exclusive ability to synthesize queuine, which is then salvaged and passed on to plants and animals. … Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from humans, cows, and goats. Humans salvage and recover queuine from either ingested food or the gut flora.
Loxapine
go.drugbank.com/drugs/DB00408ApprovedInvestigationalAn antipsychotic agent used in schizophrenia. [PubChem]
Synonyms: 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepineCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeDelandistrogene moxeparvovec
go.drugbank.com/drugs/DB16802ApprovedInvestigationalDystrophin is an essential protein responsible for muscle function; thus, patients with DMD experience a progressive deterioration of muscle mass and function. … Delandistrogene moxeparvovec is an adeno-associated virus vector-based gene therapy developed by Sarepta Therapeutics.
Simoctocog alfa
go.drugbank.com/drugs/DB09108ApprovedIt is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the factor VIII in the intrinsic pathway of blood coagulation system. … Simoctocog alfa is a glycoprotein consisting of 1440 amino acids with an approximate molecular mass of 170 kDa, comprising the FVIII domains A1-A2 + A3-C1-C2 whereas the B-domain, present in the full-length
Sulfoxone
go.drugbank.com/drugs/DB01145ApprovedSulfoxone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.
Categories: Drugs for Treatment of LepraHuman calcitonin
go.drugbank.com/drugs/DB06773Approved[A32098] It is used as an alternative for people developing antibodies against salmon calcitonin.[A32100] … Calcitonin was first discovered in isolated parathyroid tissue as a substance with a serum-calcium-lowering effect.
Evinacumab
go.drugbank.com/drugs/DB15354ApprovedInvestigationalcardiovascular risk, and it was these observations that provided a rationale for the development of a therapy targeted against ANGPTL3. … The ANGPTL family of proteins serve a number of physiologic functions - including involvement in the regulation of lipid metabolism - which have made them desirable therapeutic targets in recent years.
Oxycodegol
go.drugbank.com/drugs/DB14146InvestigationalLoxicodegol was developed by Nektar Therapeutics as an opioid analgesic with low abuse potential for the treatment of chronic pain [L3263]. … Nektar Therapeutics has filed an application for FDA approval of Loxicodegol for use in the treatment of chronic lower back pain [L3263]
Protamine sulfate
go.drugbank.com/drugs/DB09141ApprovedInvestigationalThe agent elicits this heparin reversal predominantly via the formation of an inactive complex between the anionic nature of heparin and its own cationic state [A174778, A174781, L5371]. … Since it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps
Products: PROLFAT 50 MG/5 ML IV ENJEKSİYONLUK ÇÖZELTİ, 1 ADET, PAMINTU 10 MG/ML ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON 5 ML, 10 ADET