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Clorazepic acid
go.drugbank.com/drugs/DB00628ApprovedIllicitIn September 2020, a black box warning describing these risks was included on the product label of benzodiazepines as per FDA regulation. … Similar to other benzodiazepines, the active metabolite of clorazepate enhances the binding of gamma-aminobutyric acid (GABA) to the GABA type A (GABA-A) receptor, which promotes channel opening and neuronal
Products: Tranxene T-Tab, Clorazepate Dipotassium T-TabSevabertinib
go.drugbank.com/drugs/DB21667ApprovedInvestigational[L54638] Sevabertinib functions as a reversible kinase inhibitor of human epidermal growth factor receptor 2 (HER2), also exhibiting activity against epidermal growth factor receptor (EGFR). … [L54638] It was granted accelerated approval by the FDA on November 19th, 2025.[L54608]
Opium
go.drugbank.com/drugs/DB11130ApprovedIllicitIt has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. … During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive.[A32171] Opium is extracted from _Papaver somniferum_, which is more known as poppies.
Carindacillin
go.drugbank.com/drugs/DB09319ApprovedWithdrawnCarindacillin or Carbenicillin isdanyl was an oral penicillin prodrug of [carbenicillin] marketed by Pfizer as Geocillin. It is no longer marketed in the United States.
Oteracil
go.drugbank.com/drugs/DB03209ApprovedInvestigationalThe main active ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic anti-metabolite drug that acts on rapidly dividing cancer cells. … Oteracil is an adjunct to antineoplastic therapy, used to reduce the toxic side effects associated with chemotherapy.
Serplulimab
go.drugbank.com/drugs/DB17451ApprovedInvestigationalSerplulimab is a humanized monoclonal IgG4 antibody that acts as an immune checkpoint inhibitor by targeting the programmed cell death-1 (PD-1) receptor. … It was first approved in China - where it is indicated for a number of different cancers[L52963] - and has since been approved in several southeast Asian countries.
NADH
go.drugbank.com/drugs/DB00157ApprovedNutraceuticalIt is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). … It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed)
Nirmatrelvir
go.drugbank.com/drugs/DB16691ApprovedInvestigational[L33359] In December 2021, the FDA granted an emergency use authorization to Paxlovid, a co-packaged product containing both nirmatrelvir and [ritonavir], for the treatment of certain patients with … [L39544] It was fully approved by the FDA on May 25, 2023.
Bromothalonil
go.drugbank.com/drugs/DB14199ApprovedBromothalonil, also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that can be found in many personal hygiene and industrial products. … It is also a known allergen and dermatological irritant that has been banned in many EU countries due to increasing rates of contact allergy [A34322].
Categories: Compounds used in a research, industrial, or household settingEsmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnIt has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. … Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker.