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Linerixibat
go.drugbank.com/drugs/DB11729ApprovedInvestigationalto be the primary pruritogens. … [L56127] PBC is a rare, chronic autoimmune liver disease characterized by the destruction of small bile ducts, leading to cholestasis and the systemic accumulation of bile acids, which are hypothesized
Glycopyrronium
go.drugbank.com/drugs/DB00986ApprovedInvestigationalVet approved[A233570,L33090] Later research, taking advantage of the systemic distribution of muscarinic receptors through the body, found that glycopyrronium could also be used for reducing sweat gland,[L4755] oral … [L33110] It is one of the most commonly prescribed anticholinergic medications.
Chloral hydrate
go.drugbank.com/drugs/DB01563ApprovedIllicitInvestigationalVet approvedThe safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. … A hypnotic and sedative used in the treatment of insomnia.
Products: HIDRATO DE CLORAL 10%SOLUCION ORAL(GOTAS)Imipramine
go.drugbank.com/drugs/DB00458ApprovedInvestigationalImipramine may be used to treat depression and nocturnal enuresis in children [FDA Label]. … Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Adrenergic alpha-1 Receptor AntagonistsProducts: SICOTONE - IFSA TABLETA DE 25 MG.Progesterone
go.drugbank.com/drugs/DB00396ApprovedInvestigationalVet approvedProgesterone is used in various contraceptive preparations to prevent ovulation and fertilization [T481], [A175612] as well as in other formulations to promote and support pregnancy. … A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss [A175609].
Categories: Sex Hormones and Modulators of the Genital SystemProducts: GESTAGENO®100MG CÁPSULAS DE GELATINA BLANDA, GESTAGENO® 200 MG CÁPSULAS DE GELATINA BLANDAIsoflurophate
go.drugbank.com/drugs/DB00677ApprovedWithdrawnAn irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. … Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330)
Tofacitinib
go.drugbank.com/drugs/DB08895ApprovedInvestigationalIt is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate. … Tofacitinib is marketed under the brand name Xeljanz by Pfizer.
Products: XELJANZ® XR 11 MG TABLETAS DE LIBERACIÓN MODIFICADAInclisiran
go.drugbank.com/drugs/DB14901ApprovedInvestigational[A225953,A225958] On December 11, 2020, the European Commission (EC) granted authorization for marketing inclisiran as the first and only approved siRNA for the treatment of adults with primary hypercholesterolemia … [L39593] It is marketed under the trade name Leqvio.
Fluconazole
go.drugbank.com/drugs/DB00196ApprovedInvestigationalFluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. … It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole].
Products: FLUCONAZOLEN CLORURO DE SODIO INYECCIÓN, ZOLODERAlvimopan
go.drugbank.com/drugs/DB06274ApprovedInvestigationalIt is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.
Categories: Peripheral Opioid Receptor Antagonists