Isoflurophate

DB00677ApprovedWithdrawnSmall molecule

An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it... Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically.

Mechanism: The mechanism of isoflurophate's action involves the irreversible inhibition of cholinesterase.
Curator reviewed
Primary indication: For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.Curator reviewed
Formula / weight: C₆H₁₄FO₃P · 184.1457 g/mol (avg)
Also known as: Diisopropoxyphosphoryl fluoride · Diisopropyl fluorophosphate · Diisopropyl fluorophosphonate · Diisopropyl phosphofluoridate · Diisopropyl phosphorofluoridate
Code names: T-1703 · TL 466

Resolves to

Compound

UNII12UHW9R67NCAS55-91-4ChEMBLCHEMBL1025ChEBI17941PubChem5936KEGGD00043

Clinical / RWD

RxNorm6027PharmGKBPA164748933

Structure

InChIKeyMUCZHBLJLSDCSD-UHFFFAOYSA-NSMILESCC(C)OP(F)(=O)OC(C)C

Targets

P22303ACHEP06276BCHEP02787TF

What you can answer from here — as of September 12, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

292Drug interactionsStructured to mechanism, not free text

27+ReferencesStructured and connected to the statements they support

Which drugs share a target with Isoflurophate, and which of those have an active Phase 3 trial?

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