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Displaying results 181 - 190 of 135872 in total
  1. Pathway

    Ripretinib Action Pathway

    smpdb.ca/view/SMP0126912
    Drug action

    Ripretinib's mechanism of action involves inhibiting protein kinases, including both wild type and mutant forms of platelet-derived growth factor receptor A (PDGFRA) and KIT, which are implicated in the … This medication has been shown to inhibit other genes like PDGFRB, BRAF, VEGF, and TIE2 in laboratory studies.

    Drugs: Calcium · Ripretinib
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain
  2. Pathway

    Faricimab Action Pathway

    smpdb.ca/view/SMP0126914
    Drug action

    While existing treatments like aflibercept and ranibizumab focus solely on inhibiting VEGF-A, faricimab's unique mechanism involves binding to and depleting both VEGF-A and Ang-2. … endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2).

    Drugs: Calcium · Faricimab
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain
  3. Pathway

    Edoxaban Action Pathway

    smpdb.ca/view/SMP0126436
    Drug action

    Due to the anticoagulant properties herbs and supplements with anticoagulant and antiplatelet activity should be avoided this includes garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Metabolized minimally by hydrolysis in the liver and primarily eliminated through the urine.

    Drugs: Calcium
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain
  4. Pathway

    Bivalirudin Action Pathway

    smpdb.ca/view/SMP0126441
    Drug action

    These herbs and supplements include ginger, garlic, bilberry, danshen, piracetam and ginkgo biloba. … This drug interacts with food, echinacea needs to be avoided in addition to herbs and supplements that have anticoagulant and antiplatelet activity.

    Drugs: Bivalirudin · Calcium
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain
  5. Pathway

    Aprotinin Plasminogen Antifibrinolytic Action Pathway

    smpdb.ca/view/SMP0126443
    Drug action

    The drug is slowly metabolized by lysosomal enzymes and is eliminated through the urine over 48 hours. … It slows the breakdown of fibrin clots to reduce bleeding by inhibiting the proteins plasminogen and kallikrein.

    Drugs: Calcium · Aprotinin
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain
  6. Pathway

    Alteplase Action Pathway

    smpdb.ca/view/SMP0126634
    Drug action

    Alteplase binds to fibrin and cleaves an arginine-valine bond of plasminogen converting it into its active form and acting on the fibrin matrix. … Due to its nature of anticoagulant and antiplatelet activity herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.

    Drugs: Alteplase · Calcium
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain
  7. Pathway

    Heparin Action Pathway

    smpdb.ca/view/SMP0123108
    Drug action

    Heparin is mainly used for the treatment of venous thrombosis and prevention of thrombosis and embolism following a post-op of cardiac surgery. … Some side effects include heparin-induced-thrombocytopenia caused by a loss in platelet count and the chance of a clot becoming dislodged and obstructing a blood vessel.

    Drugs: Heparin · Calcium
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain
  8. Pathway

    Certoparin Action Pathway

    smpdb.ca/view/SMP0126157
    Drug action

    Certoparin can interact with herbs and supplements, it is best to avoid those with anticoagulant and antiplatelet activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Certoparin is a heparin with a low molecular weight (LMWH), it prevents and treats venous thromboembolism.

    Drugs: Calcium · Certoparin
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain
  9. Pathway

    Enoxaparin Action Pathway

    smpdb.ca/view/SMP0126159
    Drug action

    Enoxaparin can interact with some herbs and supplements, avoid those with anticoagulant and antiplatelet activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Enoxaparin is metabolized by the liver through depolymerization and desulfation to lower molecular weight metabolites. It is eliminated by the kidneys and generally has a half-life of 4 hours.

    Drugs: Ardeparin · Calcium
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain
  10. Pathway

    Dalteparin Action Pathway

    smpdb.ca/view/SMP0126160
    Drug action

    Dalteparin can interact with herbs and supplements, avoid those with anticoagulant and antiplatelet activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … It binds to antithrombin III, inhibiting the formation of Xa and thrombin.

    Drugs: Calcium · Dalteparin
    Enzymes: Fibrinogen beta chain, Fibrinogen alpha chain