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KRN-633

Fluocinolone acetonide

Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity.

Icanbelimod

The usage of the INN stem '-imod' in the name indicates that Icanbelimod is a immunomodulator, both stimulant/suppressive and stimulant. Icanbelimod has a monoisotopic molecular weight of 409.18 Da.

Sebetralstat

This plasma kallikrein inhibitor works by reducing bradykinin, the substance that causes the characteristic swelling in HAE attacks [L53533]. The U.S. … Sebetralstat is the first and only oral on-demand treatment for HAE, providing a convenient alternative to injectable therapies that have been challenging for patients to use [L53538, A274293].

Valziflocept

Ketotifen

[A231204] In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of itchy eyes associated with allergies,[L32278] and in Canada a prescription-only oral formulation is … It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and [azatadine].

Berotralstat

Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). … [A225106] Berotralstat was first approved by the FDA on December 3, 2020, as the first once-daily oral therapy to prevent angioedema attacks of HAE in adults and pediatric patients 12 years and older.

Hypromellose

It is a commonly used as a delivery component in oral pharmaceutical products that provides the release of a drug in a controlled fashion, effectively increasing the duration of release of a drug to prolong … It acts as a thickening agent, coating polymer, bioadhesive, solubility enhancer in solid dispersions, and binder in the process of granulation and in modified release formulations [A24840].

Levonorgestrel

[L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives. … to older emergency contraceptive regimens.

Calcium carbonate

Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia. … Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.