Identification

Name

Calcium carbonate

Accession Number

DB06724

Description

Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.

Type

Small Molecule

Groups

Approved, Investigational

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Calcium carbonate (DB06724)

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Weight

Average: 100.087
Monoisotopic: 99.947335021

Chemical Formula

CCaO₃

Synonyms

• Calcio carbonato
• Calcium carbonate (1:1)
• Calciumcarbonat
• Carbonate de calcium
• Carbonato de calcio
• Carbonic acid calcium salt (1:1)
• Chalk
• Kalziumkarbonat
• Kohlensaurer kalk
• Precipitated calcium carbonate

External IDs

• CI 77220
• E 170
• E-170(I)
• INS NO.170(I)
• INS-170(I)
• NDI 443

Pharmacology

Indication

For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.

Associated Conditions

• Acid indigestion
• Heartburn
• Hyperphosphataemia
• Sour stomach

Associated Therapies

• Dietary and Nutritional Therapies

Contraindications & Blackbox Warnings

Learn about our commercial Contraindications & Blackbox Warnings data.

Learn More

Pharmacodynamics

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.

Mechanism of action

Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO₃^-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).

Absorption

Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.

Volume of distribution

Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.

Protein binding

Calcium acts as a co-factor to numerous enzymes.

Metabolism

None.

Route of elimination

Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.

Half-life

Not Available

Clearance

Not Available

Adverse Effects

Learn about our commercial Adverse Effects data.

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Toxicity

Not Available

Affected organisms

• Humans and other mammals

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
Unlock Additional Data
Abciximab	The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Abciximab.
Acebutolol	The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium carbonate.
Acenocoumarol	The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Acenocoumarol.
Acetaminophen	Calcium carbonate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetophenazine	Calcium carbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetyldigitoxin	Calcium carbonate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Alendronic acid	The serum concentration of Alendronic acid can be decreased when it is combined with Calcium carbonate.
Alfacalcidol	The risk or severity of adverse effects can be increased when Calcium carbonate is combined with Alfacalcidol.
Alimemazine	Calcium carbonate can cause a decrease in the absorption of Alimemazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol	The therapeutic efficacy of Allopurinol can be decreased when used in combination with Calcium carbonate.

Additional Data Available

Extended Description
Extended Description
Extended description of the mechanism of action and particular properties of each drug interaction.
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Severity
Severity
A severity rating for each drug interaction, from minor to major.
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Evidence Level
Evidence Level
A rating for the strength of the evidence supporting each drug interaction.
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Action
Action
An effect category for each drug interaction. Know how this interaction affects the subject drug.
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Food Interactions

• Take with or without food. Food increases the absorption of calcium carbonate, which may be advantageous in its use as a calcium supplement.

Products

Active Moieties

Name	Kind	UNII	CAS	InChI Key
Calcium	unknown	SY7Q814VUP	7440-70-2	OYPRJOBELJOOCE-UHFFFAOYSA-N
Carbonate ion	ionic	7UJQ5OPE7D	3812-32-6	BVKZGUZCCUSVTD-UHFFFAOYSA-L
Calcium cation	ionic	2M83C4R6ZB	14127-61-8	BHPQYMZQTOCNFJ-UHFFFAOYSA-N

Product Images

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Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Unlock Additional Data
7 Select Antacid	Tablet, chewable	750 mg/1	Oral	7-Eleven	2014-09-11	2020-05-01
Alka Seltzer	Tablet, chewable	750 mg/1	Oral	Bestco, Inc.	2013-02-08	Not applicable
Alka-Seltzer Cool Action Extra Strength ReliefChews Mint	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2019-03-03	Not applicable
Alka-Seltzer Cool Action Heartburn Relief Mint	Gum, chewing	750 mg/1	Oral	Bayer Healthcare Llc.	2020-03-01	Not applicable
Alka-Seltzer Extra Strength Heartburn ReliefChews	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2016-09-15	Not applicable
Alka-Seltzer Fruit Chews	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2013-03-15	2015-06-01
Alka-Seltzer Heartburn Relief Peppermint	Gum, chewing	750 mg/1	Oral	Bayer Healthcare Llc.	2020-03-02	Not applicable
Alka-Seltzer Heartburn ReliefChews	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2014-03-15	Not applicable
Alka-Seltzer Heartburn ReliefChews Cool Mint	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2014-03-15	2017-05-31
Alka-Seltzer Heartburn ReliefChews Strawberry	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2014-03-15	2017-08-31

Additional Data Available

Application Number
Application Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
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Product Code
Product Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
28tak Gum Care Tooth	Calcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g)	Paste, dentifrice	Oral	Elmeditec Co.,Ltd	2018-07-01	Not applicable
4240 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4248 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4327 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4329 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4338 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4339 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4346 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4356 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)		Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4390 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL)		Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
28tak Gum Care Tooth	Calcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g)	Paste, dentifrice	Oral	Elmeditec Co.,Ltd	2018-07-01	Not applicable
4240 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4248 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4327 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4329 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4338 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4339 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4346 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4356 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)		Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4390 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL)		Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable

Categories

ATC Codes

A02AC01 — Calcium carbonate

• A02AC — Calcium compounds
• A02A — ANTACIDS
• A02 — DRUGS FOR ACID RELATED DISORDERS
• A — ALIMENTARY TRACT AND METABOLISM

A12AA04 — Calcium carbonate

• A12AA — Calcium
• A12A — CALCIUM
• A12 — MINERAL SUPPLEMENTS
• A — ALIMENTARY TRACT AND METABOLISM

A11GB01 — Ascorbic acid (vit c) and calcium

• A11GB — Ascorbic acid (vitamin C), combinations
• A11G — ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
• A11 — VITAMINS
• A — ALIMENTARY TRACT AND METABOLISM

Drug Categories

• Acids
• Acids, Noncarboxylic
• Alimentary Tract and Metabolism
• Alkalies
• Anions
• Antacids
• Antacids and Adsorbents
• Blood Coagulation Factors
• Calcium Compounds
• Calcium Salts
• Carbon Compounds, Inorganic
• Carbonates
• Carbonic Acid
• Drugs for Acid Related Disorders
• Electrolytes
• Gastric Acid Lowering Agents
• Gastrointestinal Agents
• Ions
• Mineral Supplements
• Minerals
• Phosphate Binder
• Polyvalent cation containing laxatives, antacids, oral supplements
• Replacement Preparations

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Organic carbonic acids and derivatives

Sub Class

Organic carbonic acids

Direct Parent

Organic carbonic acids

Alternative Parents

Carbonate salts / Organic calcium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds

Substituents

Aliphatic acyclic compound / Carbonate salt / Carbonic acid / Carbonyl group / Hydrocarbon derivative / Organic calcium salt / Organic oxide / Organic oxygen compound / Organic salt / Organooxygen compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

calcium salt, one-carbon compound, carbonate salt (CHEBI:3311)

Chemical Identifiers

UNII

H0G9379FGK

CAS number

471-34-1

InChI Key

VTYYLEPIZMXCLO-UHFFFAOYSA-L

InChI

InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

IUPAC Name

calcium carbonate

SMILES

[Ca++].[O-]C([O-])=O

References

Synthesis Reference

Nobuo Someya, Tadao Kitazato, Takao Fujikawa, Yasuo Manabe, "Sintered body of calcium carbonate and process for producing same." U.S. Patent US5187125, issued May, 1940.

US5187125

General References

1. Cruz Verde: Caprimida D (calcium citrate/vitamin D) [Link]

External Links

KEGG Drug

D00932

KEGG Compound

C08129

PubChem Compound

10112

PubChem Substance

310264878

ChemSpider

9708

RxNav

1897

ChEBI

3311

ChEMBL

CHEMBL1200539

PharmGKB

PA448726

Wikipedia

Calcium_carbonate

AHFS Codes

• 56:04.00 — Antacids and Adsorbents
• 88:29.00* — Minerals
• 40:12.00 — Replacement Preparations

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Completed	Prevention	Benign Paroxysmal Positional Vertigo (BPPV)	1
4	Completed	Treatment	BMI >27 kg/m2 / BMI >30 kg/m2	1
4	Completed	Treatment	Cardiovascular Events / Hemodialysis Treatment / Hyperphosphataemia	1
4	Completed	Treatment	Chronic Hypoparathyroidism	1
4	Completed	Treatment	Diabetic Macular Edema (DME)	1
4	Completed	Treatment	Nutritional Rickets	1
4	Completed	Treatment	Stage 3 Chronic Kidney Disease	1
4	Completed	Treatment	Tooth Bleaching / Tooth Sensitivity	1
4	Enrolling by Invitation	Treatment	Bone Diseases, Metabolic / Hyperphosphataemia / Renal Insufficiency,Chronic	1
4	Not Yet Recruiting	Supportive Care	Calcium Supplementation in HIV Patients Using Raltegravir	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Paste, dentifrice	Oral
Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical
Kit	Ophthalmic; Oral; Topical
Tablet, chewable	Buccal	500 mg
Tablet, chewable	Oral	10 mg
Kit	Oral
Gum, chewing	Oral	750 mg/1
Tablet	Oral	1000 mg/1
Tablet	Oral	500 mg/1
Tablet	Oral	750 mg/1
Tablet, chewable	Oral	1000 mg/1
Tablet, chewable	Oral	750 1/1
Lozenge	Oral	750 mg/1
Tablet		500 mg
Paste	Dental	36.4 g/130g
Tablet, chewable	Oral	250 mg
Injection, solution	Parenteral	1 mg/mL
Powder, for solution	Oral
Powder, for solution	Oral	500 mg
Tablet
Tablet, effervescent	Oral	1500 mg
Tablet, chewable	Oral	500 mg/1
Tablet, effervescent	Oral	2500 mg
Tablet	Oral	1 G
Granule, effervescent	Oral	2500 mg
Tablet, effervescent	Oral	1000 mg/1
Tablet, effervescent	Oral	500 mg/1
Tablet	Oral	600 mg/1
Powder	Oral	1 g/1g
Suspension	Oral	1250 mg/5mL
Tablet	Oral	1250 mg/1
Tablet	Oral	648 mg/1
Tablet, effervescent	Oral	120 mg/1
Tablet, effervescent	Oral	300 mg
Tablet, effervescent	Oral	360 mg/1
Tablet, chewable	Oral	680 mg
Tablet, effervescent		1000 mg
Capsule	Oral
Tablet	Oral	1500 mg
Granule	Oral	2500 MG
Tablet, film coated	Oral	500 mg/1
Tablet, effervescent	Oral	240 mg
Tablet, chewable	Oral	1177 mg/1
Gum, chewing	Oral	500 mg/1
Granule	Oral	750 mg/1g
Tablet, chewable	Oral	500 mg
Tablet, chewable	Buccal	470 mg
Tablet, effervescent		500 mg
Paste, dentifrice	Topical
Liquid	Oral	1250 mg/40mL
Solution	Oral	1250 mg/34mL
Powder, dentifrice	Oral
Tablet, effervescent	Oral	100 mg
Suspension	Oral	5 g
Tablet	Oral	680 mg
Suspension	Oral	150 mg/5ml
Suspension	Oral	600 mg/5ml
Suspension	Oral	5 mg
Suspension	Oral	5 % w/v
Liquid	Oral	250 mg
Suspension	Oral	500 mg
Suspension	Oral
Capsule, delayed release	Oral	0.6 mg
Tablet, chewable	Oral
Powder	Oral	1000 mg/1
Tablet, coated	Oral	150 mcg
Tablet, film coated	Oral	600 mg/1
Paste	Oral
Tablet, chewable	Oral	350 mg/492mg
Tablet	Oral	1000 MG
Tablet, coated	Oral
Paste, dentifrice	Dental	31.25 g/100g
Tablet, coated	Oral	1579 mg
Tablet, coated	Oral	200 mg
Suspension	Oral	15 g
Capsule	Oral
Tablet	Oral	600 mg
Tablet	Oral	1250 MG
Suspension	Oral	2.5 g
Suspension	Oral	0.5 g
Tablet, chewable	Oral	420 1/1
Liquid	Oral
Capsule, liquid filled	Oral	0.6 mg
Paste	Dental
Paste	Dental	51 g/150g
Powder	Oral
Tablet	Oral
Tablet, coated	Oral	1250 mg
Tablet, coated	Oral	600 mg
Tablet, effervescent	Oral	35 mg
Tablet, coated	Oral	500 mg/1
Capsule, delayed release	Oral	150 mg
Tablet, chewable	Oral	400 mg/1
Tablet, chewable	Oral	420 mg/1
Granule, effervescent		1000 mg
Tablet, film coated	Oral
Capsule, gelatin coated	Oral
Pill	Oral
Suspension	Oral	250 mg/5ml
Liquid	Topical
Tablet, film coated		500 mg
Tablet	Oral
Wafer	Oral
Suspension	Oral	21.3 mg/ml
Suspension	Oral	267 mg/ml
Suspension	Oral	50 mg/ml
Suspension	Oral	150 mg
Suspension	Oral	680 mg
Bar, chewable	Oral	1177 mg/1
Lozenge	Oral
Bar, chewable	Oral
Tablet, chewable	Oral	648 mg/1
Powder	Topical
Paste, dentifrice	Dental	15.85 g/100g
Paste, dentifrice	Dental
Tablet, chewable	Oral	750 mg/1
Tablet, chewable	Oral	600 mg
Tablet	Oral	420 mg/1
Capsule, liquid filled	Oral	1 mg
Cream	Oral
Capsule, liquid filled	Oral	25 mg
Capsule, liquid filled	Oral
Tablet, chewable	Oral	1500 mg
Tablet, orally disintegrating	Oral	600 mg
Tablet, film coated	Oral	600 mg

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)	Region
Unlock Additional Data
US6814978	Yes	2004-11-09	2022-02-26
US6165513	Yes	2000-12-26	2018-12-10
US5994329	Yes	1999-11-30	2019-01-17
US6015801	Yes	2000-01-18	2019-01-17
US6432932	Yes	2002-08-13	2019-01-17
US6465443	Yes	2002-10-15	2019-02-14
US5989588	Yes	1999-11-23	2018-03-30

Additional Data Available

Filed On
Filed On
The date on which a patent was filed with the relevant government.
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Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	128.0 mg/mL	ALOGPS
logP	0.47	ALOGPS
logP	0.25	ChemAxon
logS	-0.08	ALOGPS
pKa (Strongest Acidic)	6.05	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	63.19 Å2	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	31.17 m3·mol-1	ChemAxon
Polarizability	3.52 Å3	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	Not Available

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Drug created on August 09, 2010 11:35 / Updated on September 25, 2020 15:13