Calcium carbonate

Identification

Summary

Calcium carbonate is an ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.

Brand Names

Alka-seltzer Fruit Chews, Alka-seltzer Heartburn Plus Gas Relief, Alkums, Bayer Womens, Cal Gest, Chooz, Diphen, Duo Fusion, Healthy Mama, Irospan 24/6 Kit, Magnebind 400 Rx, Meijer, Mi-acid Double Strength, Mylanta Tonight, Nutralox, Pepcid Complete, Pepto-bismol, Phazyme, Pregvit, Rolaids Advanced, Rolaids Reformulated Aug 2006, Rolaids Ultra Strength, Titralac, Titralac Plus, Tums

Generic Name

Calcium carbonate

DrugBank Accession Number

DB06724

Background

Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.

Type

Small Molecule

Groups

Approved, Investigational

Structure

Similar Structures

Weight: Average: 100.087
Monoisotopic: 99.947335021
Chemical Formula: CCaO₃

Synonyms

Calcio carbonato
Calcium carbonate
Calcium carbonate (1:1)
Calciumcarbonat
Carbonate de calcium
Carbonato de calcio
Carbonic acid calcium salt (1:1)
Chalk
Kalziumkarbonat
Kohlensaurer kalk
Precipitated calcium carbonate

External IDs

CI 77220
E 170
E-170(I)
INS NO.170(I)
INS-170(I)
NDI 443

Pharmacology

Indication

For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.

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Associated Conditions

Associated Therapies

Dietary supplementation

Contraindications & Blackbox Warnings

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Pharmacodynamics

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.

Mechanism of action

Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO₃^-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).

Absorption

Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.

Volume of distribution

Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.

Protein binding

Calcium acts as a co-factor to numerous enzymes.

Metabolism

None.

Route of elimination

Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Acebutolol	The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium carbonate.
Acetaminophen	Calcium carbonate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetophenazine	Calcium carbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetyldigitoxin	Calcium carbonate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Alfacalcidol	The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium carbonate.
Alimemazine	Calcium carbonate can cause a decrease in the absorption of Alimemazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol	The therapeutic efficacy of Allopurinol can be decreased when used in combination with Calcium carbonate.
Amphetamine	The serum concentration of Amphetamine can be increased when it is combined with Calcium carbonate.
Amprenavir	Calcium carbonate can cause a decrease in the absorption of Amprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Asunaprevir	Calcium carbonate can cause a decrease in the absorption of Asunaprevir resulting in a reduced serum concentration and potentially a decrease in efficacy.

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Food Interactions

Take with or without food. Food increases the absorption of calcium carbonate, which may be advantageous in its use as a calcium supplement.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Calcium	unknown	SY7Q814VUP	7440-70-2	OYPRJOBELJOOCE-UHFFFAOYSA-N
Carbonate ion	ionic	7UJQ5OPE7D	3812-32-6	BVKZGUZCCUSVTD-UHFFFAOYSA-L
Calcium cation	ionic	2M83C4R6ZB	14127-61-8	BHPQYMZQTOCNFJ-UHFFFAOYSA-N

Product Images

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
7 Select Antacid	Tablet, chewable	750 mg/1	Oral	7-Eleven	2014-09-11	2020-05-01
AI kungang	Liquid	55 g/100mL	Topical	TheJoenSpace Co,. LTD	2021-04-14	Not applicable
Alka Seltzer	Tablet, chewable	750 mg/1	Oral	Bestco, Inc.	2013-02-08	Not applicable
Alka-Seltzer Cool Action Extra Strength ReliefChews Mint	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2019-03-03	Not applicable
Alka-Seltzer Cool Action Heartburn Relief Mint	Gum, chewing	750 mg/1	Oral	Bayer Healthcare Llc.	2020-03-01	Not applicable
Alka-Seltzer Extra Strength Heartburn ReliefChews	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2016-09-15	Not applicable
Alka-Seltzer Fruit Chews	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2013-03-15	2015-06-01
Alka-Seltzer Heartburn Relief Peppermint	Gum, chewing	750 mg/1	Oral	Bayer Healthcare Llc.	2020-03-02	Not applicable
Alka-Seltzer Heartburn ReliefChews	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2014-03-15	Not applicable
Alka-Seltzer Heartburn ReliefChews Cool Mint	Tablet, chewable	750 mg/1	Oral	Bayer Healthcare Llc.	2014-03-15	2017-05-31

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
28tak Gum Care Tooth	Calcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g)	Paste, dentifrice	Oral	Elmeditec Co.,Ltd	2018-07-01	Not applicable
4240 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4248 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4327 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4329 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4338 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4339 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4346 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL)	Kit; Liquid; Ointment; Spray; Tablet	Ophthalmic; Oral; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4356 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4390 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
28tak Gum Care Tooth	Calcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g)	Paste, dentifrice	Oral	Elmeditec Co.,Ltd	2018-07-01	Not applicable
4240 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4248 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4327 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4329 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4338 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4339 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4346 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL)	Kit; Liquid; Ointment; Spray; Tablet	Ophthalmic; Oral; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4356 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Menthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4390 First Aid Kit	Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL)	Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable

Chemical Identifiers

UNII: H0G9379FGK
CAS number: 471-34-1
InChI Key: VTYYLEPIZMXCLO-UHFFFAOYSA-L
InChI: InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
IUPAC Name: calcium carbonate
SMILES: [Ca++].[O-]C([O-])=O

References

Synthesis Reference

Nobuo Someya, Tadao Kitazato, Takao Fujikawa, Yasuo Manabe, "Sintered body of calcium carbonate and process for producing same." U.S. Patent US5187125, issued May, 1940.

US5187125

General References

Cruz Verde: Caprimida D (calcium citrate/vitamin D) [Link]

External Links

KEGG Drug: D00932
KEGG Compound: C08129
PubChem Compound: 10112
PubChem Substance: 310264878
ChemSpider: 9708
RxNav: 1897
ChEBI: 3311
ChEMBL: CHEMBL1200539
PharmGKB: PA448726
Wikipedia: Calcium_carbonate

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Completed	Prevention	Benign Paroxysmal Positional Vertigo (BPPV)	1
4	Completed	Treatment	BMI >27 kg/m2 / Obesity	1
4	Completed	Treatment	Cardiovascular Events / Hemodialysis Treatment / Hyperphosphataemia	1
4	Completed	Treatment	Chronic Hypoparathyroidism	1
4	Completed	Treatment	Chronic Kidney Disease, Stage 3 (Moderate)	1
4	Completed	Treatment	Diabetic Macular Edema (DME)	1
4	Completed	Treatment	Hyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting	1
4	Completed	Treatment	Nutritional Rickets	1
4	Completed	Treatment	Pain	1
4	Completed	Treatment	Postmenopausal Osteoporosis	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Paste, dentifrice	Oral
Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical
Kit; liquid; ointment; spray; tablet	Ophthalmic; Oral; Topical
Granule, effervescent; kit; tablet	Oral
Kit	Oral
Tablet, chewable	Buccal	100 mg
Liquid	Topical	55 g/100mL
Gum, chewing	Oral	750 mg/1
Tablet	Oral	1000 mg/1
Tablet	Oral	500 mg/1
Tablet	Oral	750 mg/1
Tablet, chewable	Oral	1000 mg/1
Tablet, chewable	Oral	750 1/1
Lozenge	Oral	750 mg/1
Paste	Dental	36.4 g/130g
Injection, solution	Parenteral
Powder, for solution	Oral
Tablet	Oral	53 mg/1001
Tablet, chewable	Oral	500 mg/1
Tablet, film coated	Oral	600 mg
Granule	Oral
Tablet, effervescent	Oral	1 G
Tablet, effervescent	Oral	1000 mg/1
Tablet, effervescent	Oral	500 mg/1
Tablet	Oral	600 mg/1
Tablet, effervescent	Oral
Tablet	Oral	600 mg / tab
Tablet	Oral	650 mg / tab
Capsule	Oral	400 mg / cap
Powder	Oral	1 g/1g
Suspension	Oral	1250 mg/5mL
Tablet	Oral	1250 mg/1
Tablet	Oral	648 mg/1
Tablet	Oral	246 mg / tab
Tablet	Oral	1.5 g / tab
Tablet	Oral	1.5 g
Tablet, coated	Oral	500 mg
Tablet	Oral	625 mg / tab
Tablet	Oral	1.25 g / tab
Tablet	Oral	420 mg
Capsule	Oral	500 mg
Tablet	Oral	600.000 mg
Tablet, chewable	Buccal	500 mg
Tablet, coated	Oral	600 m
Granule, effervescent	Oral	2500 MG
Tablet, film coated	Oral	500 mg/1
Tablet, effervescent	Oral	240 mg
Liquid	Topical	3 mg/100mL
Tablet, chewable	Oral	1177 mg/1
Tablet	Oral	266.7 mg
Gum, chewing	Oral	500 mg/1
Tablet	Oral	45 mg/1001
Tablet	Oral	45 mg/1
Powder	Oral	216.7 mg / g
Tablet	Oral	10 mg/1001
Granule	Oral	750 mg/1g
Capsule	Oral	500 mg / cap
Cream; kit; liquid; ointment; tablet; tablet, chewable; tablet, film coated	Oral; Topical
Tablet, chewable	Buccal	470 mg
Paste	Oral	0.22 g/100g
Tablet	Oral	500 mg
Tablet, effervescent	Oral	500 mg
Tablet, effervescent	Oral
Tablet	Buccal
Drug delivery system	Oral
Tablet	Oral	300 mg / tab
Paste, dentifrice	Topical
Liquid	Oral	1250 mg/40mL
Solution	Oral	1250 mg/34mL
Powder, dentifrice	Oral
Tablet, chewable	Buccal
Gel	Oral
Suspension	Oral	325 MG/10ML
Tablet, chewable	Oral	187.5 MG
Suspension	Oral	160 MG/10ML
Tablet, chewable	Oral	80 MG
Tablet, chewable	Buccal	750 mg
Suspension	Oral
Capsule, delayed release	Oral
Tablet, chewable	Oral
Powder	Oral	1000 mg/1
Tablet, coated	Oral	150 mcg
Tablet, film coated	Oral	600 mg/1
Paste	Oral
Tablet, chewable	Oral	350 mg/492mg
Paste	Dental	30 g/100g
Tablet, coated	Oral
Paste, dentifrice	Dental	31.25 g/100g
Kit; tablet; tablet, film coated	Oral
Paste, dentifrice	Dental	40 g/100g
Granule, effervescent	Oral
Tablet	Oral	56 mg/1001
Syrup	Oral	1.25 g
Liquid; tablet	Oral
Suspension
Tablet	Transmucosal
Capsule	Oral
Tablet, chewable	Oral
Tablet, chewable	Oral	420 1/1
Liquid	Oral
Tablet	Oral	63 mg/1001
Capsule, liquid filled	Oral	0.6 mg
Paste	Dental
Capsule, gelatin coated; kit; tablet	Oral
Kit; tablet	Oral
Capsule, liquid filled	Oral	1 mg
Tablet	Oral	64 mg/1001
Paste	Dental	51 g/150g
Powder	Oral
Tablet, chewable	Oral	600 mg
Tablet	Oral	250 mg / tab
Tablet, film coated	Oral	400 mg
Tablet, coated	Oral	500 mg/1
Tablet, chewable	Oral	400 mg/1
Suspension	Oral	8 g
Tablet	Oral	400 mg
Tablet, chewable	Oral	420 mg/1
Tablet, film coated	Oral
Capsule, liquid filled; kit; tablet	Oral
Capsule, gelatin coated	Oral
Pill	Oral
Liquid	Topical
Tablet, film coated	Oral	500 mg
Tablet	Oral
Wafer	Oral
Tablet	Oral	200 mg / tab
Tablet	Oral
Tablet, chewable	Oral	800 mg
Tablet	Oral	680 mg
Tablet, orally disintegrating	Oral
Bar, chewable	Oral	1177 mg/1
Lozenge	Oral
Bar, chewable	Oral
Gel, dentifrice	Oral
Powder	Topical
Cream	Rectal
Tablet, chewable	Oral	648 mg/1
Tablet	Oral	250 mg
Powder	Topical
Paste, dentifrice	Dental	15.85 g/100g
Paste, dentifrice	Dental
Tablet, chewable	Oral	750 mg/1
Tablet, extended release	Oral
Kit; tablet; tablet, coated	Oral
Kit	Oral	4 g/237mL
Powder, for solution	Oral	4 g/237mL
Tablet	Oral	420 mg/1
Tablet	Oral	420 mg / tab
Capsule; kit; tablet, film coated	Oral
Lozenge	Oral	200 mg/7g
Tablet	Oral	500.000 mg
Tablet	Oral	500 mg / tab
Tablet	Oral	750 mg
Tablet	Oral	750 mg / tab
Tablet	Oral	500.02 mg
Tablet	Oral	400 mg / tab
Liquid	Oral	400 mg / tsp
Cream	Oral
Capsule; kit; tablet	Oral
Capsule, liquid filled	Oral
Kit; tablet, chewable	Oral; Topical
Capsule	Oral	350 mg
Tablet, film coated	Oral	1000 mg
Capsule	Oral	835 mg
Tablet	Oral	1000 mg
Tablet	Oral	600 mg
Tablet, coated	Oral	350 mg
Tablet, coated	Oral	835 mg
Tablet, film coated	Oral	1500 mg
Tablet, chewable	Oral	1000 mg
Tablet, film coated	Oral	1250 mg
Tablet, film coated
Tablet	Oral	350 mg
Lotion
Powder
Tablet, chewable	Oral	750 mg
Tablet, effervescent	Oral	1250 mg
Tablet, chewable	Oral	1250 mg
Tablet, chewable	Oral	1500 mg
Tablet	Oral	650 mg
Tablet, chewable	Oral	500 mg
Capsule	Oral	625 mg
Tablet	Oral	1250 mg
Tablet, coated	Oral	625 mg
Tablet, coated	Oral	1000 mg
Tablet, coated	Oral	1250 mg
Tablet, effervescent
Tablet	Oral	835 mg
Tablet, coated	Oral	600 mg
Tablet, effervescent	Oral	1000 mg
Tablet
Tablet	Oral	1500 mg

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US6814978	Yes	2004-11-09	2022-02-26
US6165513	Yes	2000-12-26	2018-12-10
US5994329	Yes	1999-11-30	2019-01-17
US6015801	Yes	2000-01-18	2019-01-17
US6432932	Yes	2002-08-13	2019-01-17
US6465443	Yes	2002-10-15	2019-02-14
US5989588	Yes	1999-11-23	2018-03-30

Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	128.0 mg/mL	ALOGPS
logP	0.47	ALOGPS
logP	0.25	Chemaxon
logS	-0.08	ALOGPS
pKa (Strongest Acidic)	3.5	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	3	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	63.19 Å²	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	31.17 m³·mol^-1	Chemaxon
Polarizability	3.52 Å³	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	Not Available

Drug created at August 09, 2010 17:35 / Updated at October 03, 2023 16:58

Calcium carbonate

Identification

Structure for Calcium carbonate (DB06724)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra