Calcium carbonate
Identification
- Name
- Calcium carbonate
- Accession Number
- DB06724
- Description
Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
- Weight
- Average: 100.087
Monoisotopic: 99.947335021 - Chemical Formula
- CCaO3
- Synonyms
- Calcio carbonato
- Calcium carbonate
- Calcium carbonate (1:1)
- Calciumcarbonat
- Carbonate de calcium
- Carbonato de calcio
- Carbonic acid calcium salt (1:1)
- Chalk
- Kalziumkarbonat
- Kohlensaurer kalk
- Precipitated calcium carbonate
- External IDs
- CI 77220
- E 170
- E-170(I)
- INS NO.170(I)
- INS-170(I)
- NDI 443
Pharmacology
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- Indication
For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.
- Associated Conditions
- Acid Reflux
- Acid indigestion
- Bloating
- Calcium Deficiency
- Calcium Metabolism Disorders
- Calcium and Vitamin D Deficiencies
- Colic
- Dyspepsia
- Gastric Ulcer
- Gastroesophageal Reflux
- Heartburn
- Hemorrhoids
- Hot Flushes
- Hyperacidity
- Hyperphosphataemia
- Hypovitaminosis D
- Low Bone Density
- Osteodystrophy
- Osteomalacia
- Osteoporosis
- Postmenopausal Osteoporosis
- Postoperative Gas
- Proctitis
- Vertebral Fractures
- Calcium loss
- Gastrointestinal ulceration
- Associated Therapies
- Contraindications & Blackbox Warnings
- Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects
- Pharmacodynamics
Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.
- Mechanism of action
Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).
- Absorption
Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.
- Volume of distribution
Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.
- Protein binding
Calcium acts as a co-factor to numerous enzymes.
- Metabolism
None.
- Route of elimination
Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
- Reduce medical errorsand improve treatment outcomes with our comprehensive & structured data on drug adverse effects.Reduce medical errors & improve treatment outcomes with our adverse effects data
- Toxicity
- Not Available
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Abciximab. Acebutolol The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium carbonate. Acenocoumarol The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Acenocoumarol. Acetaminophen Calcium carbonate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy. Acetophenazine Calcium carbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy. Acetyldigitoxin Calcium carbonate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin. Alendronic acid The serum concentration of Alendronic acid can be decreased when it is combined with Calcium carbonate. Alfacalcidol The risk or severity of adverse effects can be increased when Calcium carbonate is combined with Alfacalcidol. Alimemazine Calcium carbonate can cause a decrease in the absorption of Alimemazine resulting in a reduced serum concentration and potentially a decrease in efficacy. Allopurinol The therapeutic efficacy of Allopurinol can be decreased when used in combination with Calcium carbonate. Improve patient outcomesBuild effective decision support tools with the industry’s most comprehensive drug-drug interaction checker.Learn more - Food Interactions
- Take with or without food. Food increases the absorption of calcium carbonate, which may be advantageous in its use as a calcium supplement.
Products
- Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets
- Active Moieties
Name Kind UNII CAS InChI Key Calcium unknown SY7Q814VUP 7440-70-2 OYPRJOBELJOOCE-UHFFFAOYSA-N Carbonate ion ionic 7UJQ5OPE7D 3812-32-6 BVKZGUZCCUSVTD-UHFFFAOYSA-L Calcium cation ionic 2M83C4R6ZB 14127-61-8 BHPQYMZQTOCNFJ-UHFFFAOYSA-N - Product Images
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 7 Select Antacid Tablet, chewable 750 mg/1 Oral 7-Eleven 2014-09-11 2020-05-01 US Alka Seltzer Tablet, chewable 750 mg/1 Oral Bestco, Inc. 2013-02-08 Not applicable US Alka-Seltzer Cool Action Extra Strength ReliefChews Mint Tablet, chewable 750 mg/1 Oral Bayer Healthcare Llc. 2019-03-03 Not applicable US Alka-Seltzer Cool Action Heartburn Relief Mint Gum, chewing 750 mg/1 Oral Bayer Healthcare Llc. 2020-03-01 Not applicable US Alka-Seltzer Extra Strength Heartburn ReliefChews Tablet, chewable 750 mg/1 Oral Bayer Healthcare Llc. 2016-09-15 Not applicable US Alka-Seltzer Fruit Chews Tablet, chewable 750 mg/1 Oral Bayer Healthcare Llc. 2013-03-15 2015-06-01 US Alka-Seltzer Heartburn Relief Peppermint Gum, chewing 750 mg/1 Oral Bayer Healthcare Llc. 2020-03-02 Not applicable US Alka-Seltzer Heartburn ReliefChews Tablet, chewable 750 mg/1 Oral Bayer Healthcare Llc. 2014-03-15 Not applicable US Alka-Seltzer Heartburn ReliefChews Cool Mint Tablet, chewable 750 mg/1 Oral Bayer Healthcare Llc. 2014-03-15 2017-05-31 US Alka-Seltzer Heartburn ReliefChews Strawberry Tablet, chewable 750 mg/1 Oral Bayer Healthcare Llc. 2014-03-15 2017-08-31 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 28tak Gum Care Tooth Calcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g) Paste, dentifrice Oral Elmeditec Co.,Ltd 2018-07-01 Not applicable US 4240 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4248 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4327 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4329 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4338 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4339 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4346 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4356 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4390 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 28tak Gum Care Tooth Calcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g) Paste, dentifrice Oral Elmeditec Co.,Ltd 2018-07-01 Not applicable US 4240 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4248 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4327 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4329 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4338 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4339 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4346 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4356 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US 4390 First Aid Kit Calcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL) Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-10-18 Not applicable US
Categories
- ATC Codes
- A02AC01 — Calcium carbonate
- A02AC — Calcium compounds
- A02A — ANTACIDS
- A02 — DRUGS FOR ACID RELATED DISORDERS
- A — ALIMENTARY TRACT AND METABOLISM
- Drug Categories
- Acids
- Acids, Noncarboxylic
- Alimentary Tract and Metabolism
- Alkalies
- Anions
- Antacids
- Antacids and Adsorbents
- Blood Coagulation Factors
- Calcium Compounds
- Calcium Salts
- Carbon Compounds, Inorganic
- Carbonates
- Carbonic Acid
- Drugs for Acid Related Disorders
- Electrolytes
- Gastric Acid Lowering Agents
- Gastrointestinal Agents
- Ions
- Mineral Supplements
- Minerals
- Phosphate Binder
- Polyvalent cation containing laxatives, antacids, oral supplements
- Replacement Preparations
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Organic carbonic acids and derivatives
- Sub Class
- Organic carbonic acids
- Direct Parent
- Organic carbonic acids
- Alternative Parents
- Carbonate salts / Organic calcium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Aliphatic acyclic compound / Carbonate salt / Carbonic acid / Carbonyl group / Hydrocarbon derivative / Organic calcium salt / Organic oxide / Organic oxygen compound / Organic salt / Organooxygen compound
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- calcium salt, one-carbon compound, carbonate salt (CHEBI:3311)
Chemical Identifiers
- UNII
- H0G9379FGK
- CAS number
- 471-34-1
- InChI Key
- VTYYLEPIZMXCLO-UHFFFAOYSA-L
- InChI
- InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
- IUPAC Name
- calcium carbonate
- SMILES
- [Ca++].[O-]C([O-])=O
References
- Synthesis Reference
Nobuo Someya, Tadao Kitazato, Takao Fujikawa, Yasuo Manabe, "Sintered body of calcium carbonate and process for producing same." U.S. Patent US5187125, issued May, 1940.
US5187125- General References
- Cruz Verde: Caprimida D (calcium citrate/vitamin D) [Link]
- External Links
- KEGG Drug
- D00932
- KEGG Compound
- C08129
- PubChem Compound
- 10112
- PubChem Substance
- 310264878
- ChemSpider
- 9708
- 1897
- ChEBI
- 3311
- ChEMBL
- CHEMBL1200539
- PharmGKB
- PA448726
- Wikipedia
- Calcium_carbonate
- AHFS Codes
- 56:04.00 — Antacids and Adsorbents
- 88:29.00* — Minerals
- 40:12.00 — Replacement Preparations
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Benign Paroxysmal Positional Vertigo (BPPV) 1 4 Completed Treatment BMI >27 kg/m2 / BMI >30 kg/m2 1 4 Completed Treatment Cardiovascular Events / Hemodialysis Treatment / Hyperphosphataemia 1 4 Completed Treatment Chronic Hypoparathyroidism 1 4 Completed Treatment Diabetic Macular Edema (DME) 1 4 Completed Treatment Nutritional Rickets 1 4 Completed Treatment Pain 1 4 Completed Treatment Postmenopausal Osteoporosis 1 4 Completed Treatment Stage 3 Chronic Kidney Disease 1 4 Completed Treatment Tooth Bleaching / Tooth Sensitivity 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral 440 mg Tablet Oral 600 mg Paste, dentifrice Oral Kit Ophthalmic; Oral; Respiratory (inhalation); Topical Kit Ophthalmic; Oral; Topical Tablet, chewable Buccal 500 mg Tablet, chewable Oral 10 mg Kit Oral Tablet, chewable Buccal 100 mg Gum, chewing Oral 750 mg/1 Tablet Oral 1000 mg/1 Tablet Oral 500 mg/1 Tablet Oral 750 mg/1 Tablet, chewable Oral 1000 mg/1 Tablet, chewable Oral 750 1/1 Lozenge Oral 750 mg/1 Tablet Oral 500 mg Paste Dental 36.4 g/130g Tablet, chewable Oral 250 mg Injection, solution Parenteral 1 mg/mL Tablet, film coated Oral 15 mg Tablet, effervescent Oral 15 mg Powder, for solution Oral Tablet Oral 2500 MG Powder, for solution Oral 500 mg Capsule Oral 2 mcg Tablet Oral 1000 MG Granule Oral 1250 MG Tablet Oral 1250 MG Tablet, effervescent Oral 1500 mg Tablet, chewable Oral 1250 mg Tablet, chewable Oral 500 mg/1 Tablet, effervescent Oral 2500 mg Tablet, chewable Oral 1000 MG Tablet, effervescent Oral 1 G Tablet, coated Oral 600 mg Granule, effervescent Oral 2500 mg Tablet, effervescent Oral 1000 mg/1 Tablet, effervescent Oral 500 mg/1 Tablet Oral 600 mg/1 Tablet, chewable Oral 600 mg Powder Oral 1 g/1g Suspension Oral 1250 mg/5mL Tablet Oral 1250 mg/1 Tablet Oral 648 mg/1 Tablet, effervescent Oral 120 mg/1 Tablet, effervescent Oral 300 mg Tablet, effervescent Oral 360 mg/1 Tablet, coated Oral 500 mg Tablet, effervescent Oral 2469 mg Granule Oral 2500 mg Tablet, chewable Oral 680 mg Tablet, effervescent Oral 1000 mg Capsule Oral 500 mg Tablet Oral 1500 mg Tablet, coated Oral 600 m Tablet, film coated Oral 500 mg/1 Tablet, effervescent Oral 600 mg Tablet, effervescent Oral 240 mg Liquid Topical 3 mg/100mL Tablet, chewable Oral 1177 mg/1 Gum, chewing Oral 500 mg/1 Granule Oral 750 mg/1g Tablet, chewable Oral 500 mg Tablet, chewable Buccal 470 mg Tablet, effervescent Oral 500 mg Tablet, coated Oral 200 IU Capsule Oral 50 mcg Paste, dentifrice Topical Liquid Oral 1250 mg/40mL Solution Oral 1250 mg/34mL Suspension Oral 250 mg Tablet, film coated Oral 1500 mg Powder, dentifrice Oral Tablet, effervescent Oral 100 mg Tablet, chewable Buccal 600 mg Liquid Oral 500 mg Suspension Oral 5 g Tablet Oral 680 mg Suspension Oral 150 mg/5ml Suspension Oral 600 mg/5ml Suspension Oral 5 mg Suspension Oral 500 mg Suspension Oral 5 % w/v Suspension Oral 213 mg/10ml Liquid Oral 250 mg Suspension Oral 160 mg Tablet, chewable Oral 80 mg Tablet Oral 250 mg Tablet, chewable Buccal 750 mg Suspension Oral Capsule, delayed release Oral 0.6 mg Tablet Oral 400 mg Tablet, chewable Oral Powder Oral 1000 mg/1 Tablet, coated Oral 150 mcg Tablet, film coated Oral 600 mg/1 Paste Oral Tablet, chewable Oral 350 mg/492mg Suspension Oral 213 mg Paste Dental 30 g/100g Tablet, coated Oral Paste, dentifrice Dental 31.25 g/100g Tablet, coated Oral 1579 mg Tablet, coated Oral 200 mg Suspension Oral 15 g Syrup Oral 1.25 g Suspension 500 mg/5ml Powder Oral 71 mg Tablet Oral 71 mg Tablet Transmucosal 71 mg Capsule Oral Granule, effervescent Oral 2500 mg/8g Tablet, chewable Oral 10 mcg Tablet, chewable Oral 400 IU Suspension Oral 2.5 g Suspension Oral 0.5 g Tablet, chewable Oral 420 1/1 Liquid Oral Tablet, orally disintegrating Oral 1500 MG Capsule, liquid filled Oral 0.6 mg Paste Dental Tablet, chewable Oral 800 mg Tablet, chewable Oral 0.279 g Tablet Oral 270 mg Tablet, chewable Oral 270 mg Tablet Oral 200 mg Liquid Oral 160 mg/10ml Tablet, chewable Oral 200 mcg Paste Dental 51 g/150g Capsule Oral 3000 IU Powder Oral Tablet, coated Oral 1250 mg Tablet, film coated Oral 400 mg Tablet, effervescent Oral 35 mg Tablet, coated Oral 500 mg/1 Capsule, delayed release Oral 70 mg Tablet, chewable Oral 400 mg/1 Suspension Oral 8 g Tablet, chewable Oral 420 mg/1 Granule, effervescent Oral 1000 mg Tablet Oral 1500 g Tablet, film coated Oral Capsule, gelatin coated Oral Pill Oral Tablet, chewable Oral 165 mg Suspension Oral 250 mg/5ml Liquid Topical Tablet, film coated Oral 500 mg Tablet Oral Wafer Oral Suspension Oral 21.3 mg/ml Suspension Oral 267 mg/ml Suspension Oral 50 mg/ml Tablet Oral 800 MG Lozenge Oral 80 mg Lozenge Oral 680 mg Suspension Oral 150 mg Suspension Oral 680 mg Tablet, orally disintegrating Oral 1000 UI Bar, chewable Oral 1177 mg/1 Lozenge Oral Bar, chewable Oral Powder Topical 90 g/100g Cream Rectal 8 g/100g Tablet, chewable Oral 648 mg/1 Powder Topical Tablet, chewable Oral 750 mg Paste, dentifrice Dental 15.85 g/100g Paste, dentifrice Dental Tablet Oral 200 IU Tablet, chewable Oral 750 mg/1 Tablet Oral 420 mg/1 Capsule, liquid filled Oral 1 mg Tablet Oral 750 mg Tablet Oral Tablet Oral 500.02 mg Cream Oral Capsule, liquid filled Oral 25 mg Capsule, liquid filled Oral Tablet, chewable Oral 1500 mg Tablet, orally disintegrating Oral 600 mg Tablet, film coated Oral 600 mg Capsule Oral 350 mg Tablet, film coated Oral 1000 mg Capsule Oral 835 mg Tablet, coated Oral Tablet, chewable Oral Tablet, film coated Oral 1250 mg Tablet, film coated Tablet Oral 350 mg Suspension Lotion Powder Tablet, effervescent Oral 1250 mg Tablet, effervescent Oral Tablet Oral 650 mg Capsule Oral 625 mg Capsule Tablet, effervescent Tablet Oral 835 mg Tablet - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US6814978 Yes 2004-11-09 2022-02-26 US US6165513 Yes 2000-12-26 2018-12-10 US US5994329 Yes 1999-11-30 2019-01-17 US US6015801 Yes 2000-01-18 2019-01-17 US US6432932 Yes 2002-08-13 2019-01-17 US US6465443 Yes 2002-10-15 2019-02-14 US US5989588 Yes 1999-11-23 2018-03-30 US
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 128.0 mg/mL ALOGPS logP 0.47 ALOGPS logP 0.25 ChemAxon logS -0.08 ALOGPS pKa (Strongest Acidic) 6.05 ChemAxon Physiological Charge -1 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 63.19 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 31.17 m3·mol-1 ChemAxon Polarizability 3.52 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available
Drug created on August 09, 2010 17:35 / Updated on February 24, 2021 19:34