Calcium carbonate

Identification

Name
Calcium carbonate
Accession Number
DB06724
Description

Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 100.087
Monoisotopic: 99.947335021
Chemical Formula
CCaO3
Synonyms
  • Calcio carbonato
  • Calcium carbonate
  • Calcium carbonate (1:1)
  • Calciumcarbonat
  • Carbonate de calcium
  • Carbonato de calcio
  • Carbonic acid calcium salt (1:1)
  • Chalk
  • Kalziumkarbonat
  • Kohlensaurer kalk
  • Precipitated calcium carbonate
External IDs
  • CI 77220
  • E 170
  • E-170(I)
  • INS NO.170(I)
  • INS-170(I)
  • NDI 443

Pharmacology

Pharmacology
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Indication

For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body.

Mechanism of action

Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate).

Absorption

Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.

Volume of distribution

Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.

Protein binding

Calcium acts as a co-factor to numerous enzymes.

Metabolism

None.

Route of elimination

Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.

Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Abciximab.
AcebutololThe therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium carbonate.
AcenocoumarolThe therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Acenocoumarol.
AcetaminophenCalcium carbonate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
AcetophenazineCalcium carbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AcetyldigitoxinCalcium carbonate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium carbonate.
AlfacalcidolThe risk or severity of adverse effects can be increased when Calcium carbonate is combined with Alfacalcidol.
AlimemazineCalcium carbonate can cause a decrease in the absorption of Alimemazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AllopurinolThe therapeutic efficacy of Allopurinol can be decreased when used in combination with Calcium carbonate.
Interactions
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Food Interactions
  • Take with or without food. Food increases the absorption of calcium carbonate, which may be advantageous in its use as a calcium supplement.

Products

Products
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Active Moieties
NameKindUNIICASInChI Key
CalciumunknownSY7Q814VUP7440-70-2OYPRJOBELJOOCE-UHFFFAOYSA-N
Carbonate ionionic7UJQ5OPE7D3812-32-6BVKZGUZCCUSVTD-UHFFFAOYSA-L
Calcium cationionic2M83C4R6ZB14127-61-8BHPQYMZQTOCNFJ-UHFFFAOYSA-N
Product Images
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
7 Select AntacidTablet, chewable750 mg/1Oral7-Eleven2014-09-112020-05-01US flag
Alka SeltzerTablet, chewable750 mg/1OralBestco, Inc.2013-02-08Not applicableUS flag
Alka-Seltzer Cool Action Extra Strength ReliefChews MintTablet, chewable750 mg/1OralBayer Healthcare Llc.2019-03-03Not applicableUS flag
Alka-Seltzer Cool Action Heartburn Relief MintGum, chewing750 mg/1OralBayer Healthcare Llc.2020-03-01Not applicableUS flag
Alka-Seltzer Extra Strength Heartburn ReliefChewsTablet, chewable750 mg/1OralBayer Healthcare Llc.2016-09-15Not applicableUS flag
Alka-Seltzer Fruit ChewsTablet, chewable750 mg/1OralBayer Healthcare Llc.2013-03-152015-06-01US flag
Alka-Seltzer Heartburn Relief PeppermintGum, chewing750 mg/1OralBayer Healthcare Llc.2020-03-02Not applicableUS flag
Alka-Seltzer Heartburn ReliefChewsTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-15Not applicableUS flag
Alka-Seltzer Heartburn ReliefChews Cool MintTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-152017-05-31US flag
Alka-Seltzer Heartburn ReliefChews StrawberryTablet, chewable750 mg/1OralBayer Healthcare Llc.2014-03-152017-08-31US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
28tak Gum Care ToothCalcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUS flag
4240 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4248 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4327 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4329 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4338 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4339 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4346 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL)KitOphthalmic; Oral; TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4356 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4390 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
28tak Gum Care ToothCalcium carbonate (36.0 g/120g) + Alcloxa (0.12 g/120g) + Aminocaproic acid (0.12 g/120g) + Calcium phosphate, dibasic (0.12 g/120g)Paste, dentifriceOralElmeditec Co.,Ltd2018-07-01Not applicableUS flag
4240 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4248 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Caffeine (32.4 mg/1) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Tetrahydrozoline hydrochloride (0.05 g/100mL) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4327 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4329 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4338 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzalkonium chloride (0.13 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4339 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (500 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4346 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (110 mg/1) + Acetylsalicylic acid (162 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Caffeine (32.4 mg/1) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Salicylamide (152 mg/1) + Water (98.6 mL/100mL)KitOphthalmic; Oral; TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4356 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4390 First Aid KitCalcium carbonate (420 mg/1) + Acetaminophen (325 mg/1) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (0.13 g/100mL) + Ethanol (62 mL/100mL) + Ibuprofen (200 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag

Categories

ATC Codes
A02AC01 — Calcium carbonateA12AA04 — Calcium carbonateA11GB01 — Ascorbic acid (vit c) and calcium
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic carbonic acids and derivatives
Sub Class
Organic carbonic acids
Direct Parent
Organic carbonic acids
Alternative Parents
Carbonate salts / Organic calcium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Aliphatic acyclic compound / Carbonate salt / Carbonic acid / Carbonyl group / Hydrocarbon derivative / Organic calcium salt / Organic oxide / Organic oxygen compound / Organic salt / Organooxygen compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
calcium salt, one-carbon compound, carbonate salt (CHEBI:3311)

Chemical Identifiers

UNII
H0G9379FGK
CAS number
471-34-1
InChI Key
VTYYLEPIZMXCLO-UHFFFAOYSA-L
InChI
InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
IUPAC Name
calcium carbonate
SMILES
[Ca++].[O-]C([O-])=O

References

Synthesis Reference

Nobuo Someya, Tadao Kitazato, Takao Fujikawa, Yasuo Manabe, "Sintered body of calcium carbonate and process for producing same." U.S. Patent US5187125, issued May, 1940.

US5187125
General References
  1. Cruz Verde: Caprimida D (calcium citrate/vitamin D) [Link]
KEGG Drug
D00932
KEGG Compound
C08129
PubChem Compound
10112
PubChem Substance
310264878
ChemSpider
9708
RxNav
1897
ChEBI
3311
ChEMBL
CHEMBL1200539
PharmGKB
PA448726
Wikipedia
Calcium_carbonate
AHFS Codes
  • 56:04.00 — Antacids and Adsorbents
  • 88:29.00* — Minerals
  • 40:12.00 — Replacement Preparations

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionBenign Paroxysmal Positional Vertigo (BPPV)1
4CompletedTreatmentBMI >27 kg/m2 / BMI >30 kg/m21
4CompletedTreatmentCardiovascular Events / Hemodialysis Treatment / Hyperphosphataemia1
4CompletedTreatmentChronic Hypoparathyroidism1
4CompletedTreatmentDiabetic Macular Edema (DME)1
4CompletedTreatmentNutritional Rickets1
4CompletedTreatmentPain1
4CompletedTreatmentPostmenopausal Osteoporosis1
4CompletedTreatmentStage 3 Chronic Kidney Disease1
4CompletedTreatmentTooth Bleaching / Tooth Sensitivity1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral440 mg
TabletOral600 mg
Paste, dentifriceOral
KitOphthalmic; Oral; Respiratory (inhalation); Topical
KitOphthalmic; Oral; Topical
Tablet, chewableBuccal500 mg
Tablet, chewableOral10 mg
KitOral
Tablet, chewableBuccal100 mg
Gum, chewingOral750 mg/1
TabletOral1000 mg/1
TabletOral500 mg/1
TabletOral750 mg/1
Tablet, chewableOral1000 mg/1
Tablet, chewableOral750 1/1
LozengeOral750 mg/1
TabletOral500 mg
PasteDental36.4 g/130g
Tablet, chewableOral250 mg
Injection, solutionParenteral1 mg/mL
Tablet, film coatedOral15 mg
Tablet, effervescentOral15 mg
Powder, for solutionOral
TabletOral2500 MG
Powder, for solutionOral500 mg
CapsuleOral2 mcg
TabletOral1000 MG
GranuleOral1250 MG
TabletOral1250 MG
Tablet, effervescentOral1500 mg
Tablet, chewableOral1250 mg
Tablet, chewableOral500 mg/1
Tablet, effervescentOral2500 mg
Tablet, chewableOral1000 MG
Tablet, effervescentOral1 G
Tablet, coatedOral600 mg
Granule, effervescentOral2500 mg
Tablet, effervescentOral1000 mg/1
Tablet, effervescentOral500 mg/1
TabletOral600 mg/1
Tablet, chewableOral600 mg
PowderOral1 g/1g
SuspensionOral1250 mg/5mL
TabletOral1250 mg/1
TabletOral648 mg/1
Tablet, effervescentOral120 mg/1
Tablet, effervescentOral300 mg
Tablet, effervescentOral360 mg/1
Tablet, coatedOral500 mg
Tablet, effervescentOral2469 mg
GranuleOral2500 mg
Tablet, chewableOral680 mg
Tablet, effervescentOral1000 mg
CapsuleOral500 mg
TabletOral1500 mg
Tablet, coatedOral600 m
Tablet, film coatedOral500 mg/1
Tablet, effervescentOral600 mg
Tablet, effervescentOral240 mg
LiquidTopical3 mg/100mL
Tablet, chewableOral1177 mg/1
Gum, chewingOral500 mg/1
GranuleOral750 mg/1g
Tablet, chewableOral500 mg
Tablet, chewableBuccal470 mg
Tablet, effervescentOral500 mg
Tablet, coatedOral200 IU
CapsuleOral50 mcg
Paste, dentifriceTopical
LiquidOral1250 mg/40mL
SolutionOral1250 mg/34mL
SuspensionOral250 mg
Tablet, film coatedOral1500 mg
Powder, dentifriceOral
Tablet, effervescentOral100 mg
Tablet, chewableBuccal600 mg
LiquidOral500 mg
SuspensionOral5 g
TabletOral680 mg
SuspensionOral150 mg/5ml
SuspensionOral600 mg/5ml
SuspensionOral5 mg
SuspensionOral500 mg
SuspensionOral5 % w/v
SuspensionOral213 mg/10ml
LiquidOral250 mg
SuspensionOral160 mg
Tablet, chewableOral80 mg
TabletOral250 mg
Tablet, chewableBuccal750 mg
SuspensionOral
Capsule, delayed releaseOral0.6 mg
TabletOral400 mg
Tablet, chewableOral
PowderOral1000 mg/1
Tablet, coatedOral150 mcg
Tablet, film coatedOral600 mg/1
PasteOral
Tablet, chewableOral350 mg/492mg
SuspensionOral213 mg
PasteDental30 g/100g
Tablet, coatedOral
Paste, dentifriceDental31.25 g/100g
Tablet, coatedOral1579 mg
Tablet, coatedOral200 mg
SuspensionOral15 g
SyrupOral1.25 g
Suspension500 mg/5ml
PowderOral71 mg
TabletOral71 mg
TabletTransmucosal71 mg
CapsuleOral
Granule, effervescentOral2500 mg/8g
Tablet, chewableOral10 mcg
Tablet, chewableOral400 IU
SuspensionOral2.5 g
SuspensionOral0.5 g
Tablet, chewableOral420 1/1
LiquidOral
Tablet, orally disintegratingOral1500 MG
Capsule, liquid filledOral0.6 mg
PasteDental
Tablet, chewableOral800 mg
Tablet, chewableOral0.279 g
TabletOral270 mg
Tablet, chewableOral270 mg
TabletOral200 mg
LiquidOral160 mg/10ml
Tablet, chewableOral200 mcg
PasteDental51 g/150g
CapsuleOral3000 IU
PowderOral
Tablet, coatedOral1250 mg
Tablet, film coatedOral400 mg
Tablet, effervescentOral35 mg
Tablet, coatedOral500 mg/1
Capsule, delayed releaseOral70 mg
Tablet, chewableOral400 mg/1
SuspensionOral8 g
Tablet, chewableOral420 mg/1
Granule, effervescentOral1000 mg
TabletOral1500 g
Tablet, film coatedOral
Capsule, gelatin coatedOral
PillOral
Tablet, chewableOral165 mg
SuspensionOral250 mg/5ml
LiquidTopical
Tablet, film coatedOral500 mg
TabletOral
WaferOral
SuspensionOral21.3 mg/ml
SuspensionOral267 mg/ml
SuspensionOral50 mg/ml
TabletOral800 MG
LozengeOral80 mg
LozengeOral680 mg
SuspensionOral150 mg
SuspensionOral680 mg
Tablet, orally disintegratingOral1000 UI
Bar, chewableOral1177 mg/1
LozengeOral
Bar, chewableOral
PowderTopical90 g/100g
CreamRectal8 g/100g
Tablet, chewableOral648 mg/1
PowderTopical
Tablet, chewableOral750 mg
Paste, dentifriceDental15.85 g/100g
Paste, dentifriceDental
TabletOral200 IU
Tablet, chewableOral750 mg/1
TabletOral420 mg/1
Capsule, liquid filledOral1 mg
TabletOral750 mg
TabletOral
TabletOral500.02 mg
CreamOral
Capsule, liquid filledOral25 mg
Capsule, liquid filledOral
Tablet, chewableOral1500 mg
Tablet, orally disintegratingOral600 mg
Tablet, film coatedOral600 mg
CapsuleOral350 mg
Tablet, film coatedOral1000 mg
CapsuleOral835 mg
Tablet, coatedOral
Tablet, chewableOral
Tablet, film coatedOral1250 mg
Tablet, film coated
TabletOral350 mg
Suspension
Lotion
Powder
Tablet, effervescentOral1250 mg
Tablet, effervescentOral
TabletOral650 mg
CapsuleOral625 mg
Capsule
Tablet, effervescent
TabletOral835 mg
Tablet
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US6814978Yes2004-11-092022-02-26US flag
US6165513Yes2000-12-262018-12-10US flag
US5994329Yes1999-11-302019-01-17US flag
US6015801Yes2000-01-182019-01-17US flag
US6432932Yes2002-08-132019-01-17US flag
US6465443Yes2002-10-152019-02-14US flag
US5989588Yes1999-11-232018-03-30US flag

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility128.0 mg/mLALOGPS
logP0.47ALOGPS
logP0.25ChemAxon
logS-0.08ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area63.19 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity31.17 m3·mol-1ChemAxon
Polarizability3.52 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Drug created on August 09, 2010 17:35 / Updated on February 24, 2021 19:34