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Sildenafil
go.drugbank.com/drugs/DB00203ApprovedInvestigationalThe result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: Pb-sildenafil, SILDENAFIL DOC GENERICIEthanol
go.drugbank.com/drugs/DB00898ApprovedInvestigationalA clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: TEN Hand Sanitizer, P P International Inc. Hand SanitizerVurolenatide
go.drugbank.com/drugs/DB18440InvestigationalVurolenatide is a recombinant fusion protein comprising exenatide and XTEN.
Synonyms: GLP-1-XTEN, XTEN-GLP1Nirmatrelvir
go.drugbank.com/drugs/DB16691ApprovedInvestigational[A234224,A234229,A234234] In 2020, Pfizer was investigating another potential treatment for SARS-CoV-2, [PF-07304814]. … Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CL<sup>PRO</sup>) inhibitor that is the subject of clinical trial NCT04756531.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesMifamurtide
go.drugbank.com/drugs/DB13615ApprovedInvestigationalAlso called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is a synthetic, less pyrogenic, and longer-acting derivative of muramyl dipeptide (MDP). … The overall result of MDP recognition leads to the production of proinflammatory cytokines and promotion of bactericidal and tumoricidal effects [A31745].
F-box/WD repeat-containing protein 1A
go.drugbank.com/bio_entities/BE0021224TargetHumansMediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:18354482, PubMed:21258371).
Polypeptides: F-box/WD repeat-containing protein 1ABaloxavir marboxil
go.drugbank.com/drugs/DB13997ApprovedInvestigationalBaloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation. It is a prodrug of baloxavir with an impro...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesElagolix
go.drugbank.com/drugs/DB11979ApprovedInvestigationalIn particular, estimates suggest that one in ten women of reproductive age is affected by endometriosis and experience debilitating pain symptoms [A35868, A35869, F801]. … Moreover, women who are affected by this condition can suffer for up to six to ten years and visit multiple physicians before receiving a proper diagnosis [A35868, A35869, F801].
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsTramadol
go.drugbank.com/drugs/DB00193ApprovedInvestigationalTramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of actio...
Mixtures: DUODUET - PT, AUROMYOTRAM-P ® TABLETASCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesHydrocortisone
go.drugbank.com/drugs/DB00741ApprovedInvestigationalVet approvedHydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 1...
Categories: P-glycoprotein inducers, P-glycoprotein substratesProducts: K & P HYDROCORT 1 % CREME, PS-2896 Hydrocortisone Cream 1%, 0.9g