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Displaying results 181 - 190 of 180585 in total
  1. Drug

    Nefazodone

    go.drugbank.com/drugs/DB01149
    ApprovedWithdrawn

    Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to … Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury.

    Synonyms: 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-oneCategories: Adrenergic alpha-1 Receptor Antagonists, Heterocyclic Compounds, 1-Ring
  2. Drug

    Cefradine

    go.drugbank.com/drugs/DB01333
    ApprovedWithdrawn

    A semi-synthetic cephalosporin antibiotic.

    Synonyms: (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, (6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidCategories: MATE 1 Substrates, Cytochrome P-450 CYP3A Inducers
  3. Drug

    Prasterone sulfate

    go.drugbank.com/drugs/DB05804
    Investigational

    DHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin. DHEA-S is elevated with hyperprolactinemia.

    Categories: Cytochrome P-450 CYP3A7 Substrates, 17-KetosteroidsSynonyms: (3-beta)-3-(Sulfooxy)androst-5-en-17-one, 17-Ketoandrost-5-en-3beta-yl sulfate
  4. Drug

    Lumacaftor

    go.drugbank.com/drugs/DB09280
    ApprovedInvestigational

    improvement of at least 5%. … [A18395] The next most common mutation, G551D, affecting 4-5% of CF patients worldwide, is characterized as a missense mutation, whereby there is sufficient amount of protein at the cell surface, but opening

    Synonyms: 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acidCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2B6 Inducers
  5. Drug

    Ertugliflozin

    go.drugbank.com/drugs/DB11827
    ApprovedInvestigational

    Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. … [A31581] Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018.[L48621]

    Mixtures: สเตกกลูแจน (15 มิลลิกรัม/100 มิลลิกรัม), สเตกกลูแจน (15 มิลลิกรัม/100 มิลลิกรัม)Categories: P-glycoprotein substrates, Sodium-Glucose Transporter 2 Inhibitors
  6. Drug

    Phenobarbital

    go.drugbank.com/drugs/DB01174
    ApprovedInvestigational

    A barbituric acid derivative that acts as a nonselective central nervous system depressant. … It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.

    Mixtures: PIROFEN 200 MG/15 MG SUPPOZITUAR, 5 ADET, PIROFEN 200 MG/15 MG SUPPOZITUAR, 50 ADETCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates with a Narrow Therapeutic Index
  7. Drug

    Dinoprostone

    go.drugbank.com/drugs/DB00917
    ApprovedInvestigational

    Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. … As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.

    Categories: Prostaglandins ESynonyms: (Z)-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid, (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid
  8. Drug

    Leucovorin

    go.drugbank.com/drugs/DB00650
    ApprovedInvestigational

    [L56091, L56092] Additionally, it is used in combination with 5-fluorouracil (5-FU) to enhance therapeutic efficacy in the palliative treatment of advanced colorectal cancer and to treat megaloblastic … Leucovorin, also known as folinic acid or citrovorum factor, is a reduced form of folic acid that serves as a vital coenzyme in nucleic acid synthesis.

    Mixtures: FERPLEX FOL 40 MG + 0.185 MG/15 ML ORAL ÇÖZELTİ, 10 ADET, KOMFER FOL 40 MG/185 MCG ORAL COZELTI, 10 FLK.Categories: Compounds used in a research, industrial, or household setting, Vitamin B Complex
  9. Drug

    Moxonidine

    go.drugbank.com/drugs/DB09242
    ApprovedInvestigationalWithdrawn

    Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. … It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive.

    Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-2 Receptor AgonistsSynonyms: (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8- quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
  10. Drug

    (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol

    go.drugbank.com/drugs/DB07530
    Experimental

    Synonyms: (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol