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Brexpiprazole
go.drugbank.com/drugs/DB09128ApprovedInvestigationalBrexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. A...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTechnetium Tc-99m tetrofosmin
go.drugbank.com/drugs/DB09160ApprovedTechnetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and w...
Categories: P-glycoprotein substratesEtizolam
go.drugbank.com/drugs/DB09166InvestigationalEtizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxio...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesButyrfentanyl
go.drugbank.com/drugs/DB09173ExperimentalIllicitButyrfentanyl or butyrylfentanyl (not to be confused with 3-methylfentanyl) is a potent short-acting synthetic opioid analgesic drug. It is an analog of fentanyl with roughly 1/30 the potency. Butyrfentanyl was first synthesized in 1961 ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesRivoglitazone
go.drugbank.com/drugs/DB09200InvestigationalRivoglitazone (INN) is a thiazolidinedione undergoing research for use in the treatment of type 2 diabetes. It is being developed by Daiichi Sankyo Co.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsDexibuprofen
go.drugbank.com/drugs/DB09213ApprovedWithdrawnDexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. It is proposed to be more pharmacologically ...
Synonyms: (+)-(S)-p-isobutylhydratropic acidCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesAzelnidipine
go.drugbank.com/drugs/DB09230InvestigationalAzelnidipine is a dihydropyridine calcium channel blocker. It is marketed by Daiichi-Sankyo pharmaceuticals, Inc. in Japan. It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a small increa...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesLacidipine
go.drugbank.com/drugs/DB09236ApprovedLacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia . It displays specificity in the vascular smoo...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: LACIDIPINA DOC GENERICINiguldipine
go.drugbank.com/drugs/DB09239ExperimentalNiguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesNiludipine
go.drugbank.com/drugs/DB09240ExperimentalNiludipine is a calcium channel blocker.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates