Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which... It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit which yields an injection.
- Mechanism
- Curator reviewed · 2 references
The mechanism for the uptake and retention of technetium-99m tetrofosmin is not well established. Nonetheless, it is known that technetium 99m tetrofosmin binds to the intracellular cytosol of myocytes. This uptake is thought to be because technetium-99m tetrofosmin is a lipophilic cationic agent which allows it to present a passive diffusion process. Once the uptake is done, the technetium-99m accumulates in viable myocardial tissue delineating the infarcts areas when administered at rest and delineating the ischemic areas when administered at stress.
- Primary indication
- Technetium-99m tetrofosmin is indicated for the diagnosis of heart abnormalities by exercise myocardial scintigraphy.Curator reviewed
- Formula / weight
- C36H84O10P4Tc · 898.86 g/mol (avg)
- Also known as
- Tc-99m tetrofosmin · Technetium (99mTc) tetrofosmin · Technetium Tc 99m tetrofosmin · Technetium-99 tetrofosmin
- Code names
- PPN-1011
Resolves to
HBJYDUADMKVTGP-RCUQKECRSA-NSMILESO.O.[98Tc].CCOCCP(CCOCC)CCP(CCOCC)CCOCC.CCOCCP(CCOCC)CCP(CCOCC)CCOCCWhat you can answer from here — as of August 16, 2026
Which companies are running trials of Technetium Tc-99m tetrofosmin, in which indications and phases, and which of those programs are still active?
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