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Sonidegib
go.drugbank.com/drugs/DB09143ApprovedInvestigationalSonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridin-3-yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamideGadofosveset trisodium
go.drugbank.com/drugs/DB06705ApprovedGadofosveset trisodium is an intravenous contrast agent used with magnetic resonance angiography(MRA), which is a non-invasive way of imaging blood vessels.
Categories: Compounds used in a research, industrial, or household settingTarlatamab
go.drugbank.com/drugs/DB17256ApprovedInvestigational[L50748] It is a bispecific monoclonal antibody that targets CD3 expressed on the surface of T-cells and delta-like ligand 3 (DLL3), an inhibitory ligand that suppresses Notch signaling and is highly expressed … [L50743] Tarlatamab-dlle was approved by the FDA in May 2024 for use in patients who have failed previous round of platinum-based chemotherapy,[L50743,L50748] becoming the first DLL3-targeting bispecific
Synonyms: Immunoglobulin scfv-scfv-scfc, anti-(homo sapiens dll3 (delta-like ligand 3)) and anti-(homo sapiens cd3e (cd3 epsilon, leu-4)), monoclonal antibody single chain (scfv)2-scfc, bispecificDesogestrel
go.drugbank.com/drugs/DB00304ApprovedInvestigational[A176339] It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological activity. … Desogestrel, a prodrug, is a third generation progestogen[A176315] and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada.
Mixtures: O - ZETTE, MERCILON® TABLETACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTechnetium Tc-99m tetrofosmin
go.drugbank.com/drugs/DB09160ApprovedIt is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit which yields an injection. … Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging.
Categories: P-glycoprotein substrates, Compounds used in a research, industrial, or household settingVoretigene neparvovec
go.drugbank.com/drugs/DB13932ApprovedInvestigationalVoretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy.[L1094] An adeno-associated virus is a small virus that infects humans and other primates. … [A31477] An advantage of this adeno-associated virus is the high predictability, unlike retrovirus, as they associate with a specific region of the human cellular genome localized in the chromosome 19.
Hemoglobin
go.drugbank.com/drugs/DB04945ApprovedInvestigationalWithdrawnThe respiratory protein of the red blood cells. It consists primarily of globin and heme.
Chaetomium globosum
go.drugbank.com/drugs/DB10430ApprovedChaetomium globosum is a fungus which can provoke allergic reactions. Chaetomium globosum extract is used in allergenic testing.
Mixtures: A Mold Mixture, A Mold MixtureCladosporium sphaerospermum
go.drugbank.com/drugs/DB10432ApprovedCladosporium sphaerospermum is a fungus which can provoke allergic reactions. Cladosporium sphaerospermum extract is used in allergenic testing.
Mixtures: Mold Mix 3, Mold Mix 3Ustilago tritici
go.drugbank.com/drugs/DB10444ApprovedUstilago tritici is a fungus which can provoke allergic reactions. Ustilago tritici extract is used in allergenic testing.