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Displaying results 1971 - 1980 of 3601 in total
  1. Drug

    Medical Cannabis

    go.drugbank.com/drugs/DB14009
    Investigational

    The use of the plant species _Cannabis sativa_ and _Cannabis indica_, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical conditions as a … In contrast to THC's weak agonist activity, CBD has been shown to act as a negative allosteric modulator of the cannabinoid CB1 receptor, the most abundant G-Protein Coupled Receptor (GPCR) in the body

    Categories: Cytochrome P-450 CYP1A2 Inducers, P-glycoprotein inhibitors
  2. Target

    TIR domain-containing adapter molecule 1

    go.drugbank.com/bio_entities/BE0016552
    TargetHumans

    Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:125390...

    Synonyms: Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
  3. Target

    Calcium-activated potassium channel

    go.drugbank.com/bio_entities/BE0004906
    TargetHumans

    Possibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic

    Synonyms: Charybdotoxin receptor subunit beta-1, Charybdotoxin receptor subunit beta-2
  4. Drug

    Polymyxin B

    go.drugbank.com/drugs/DB00781
    ApprovedInvestigationalVet approved

    Polymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxi...

    Mixtures: OTEK-P EAR DROPS, PS-2261 Triple Antibiotic, 0.5g
  5. Drug

    JNJ-55308942

    go.drugbank.com/drugs/DB19110
    Investigational

    JNJ-55308942 is under investigation in clinical trial NCT05328297 (A Study of JNJ-55308942 in the Treatment of Bipolar Depression).

    Categories: Purinergic P2 Receptor Antagonists, Purinergic P2X Receptor Antagonists
  6. Drug

    LJ-2698

    go.drugbank.com/drugs/DB18018
    Experimental

    Categories: Purinergic P1 Receptor Antagonists, Adenosine A3 Receptor Antagonists
  7. Drug

    Vipadenant

    go.drugbank.com/drugs/DB06625
    Investigational

    Categories: Purinergic P1 Receptor Antagonists, Adenosine A2 Receptor Antagonists
  8. Drug

    Naxifylline

    go.drugbank.com/drugs/DB06471
    Experimental

    Categories: Purinergic P1 Receptor Antagonists, Adenosine A1 Receptor Antagonists
  9. Drug

    Namodenoson

    go.drugbank.com/drugs/DB12885
    Investigational

    Namodenoson has been used in trials studying the treatment of Chronic Hepatitis C and Hepatocellular Carcinoma.

    Categories: Purinergic P1 Receptor Agonists
  10. Drug

    DPCPX

    go.drugbank.com/drugs/DB12946
    Investigational

    CPX has been used in trials studying the treatment of Cystic Fibrosis.

    Categories: Purinergic P1 Receptor Antagonists, Adenosine A1 Receptor Antagonists