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Insulin (New)
smpdb.ca/view/SMP0127691PhysiologicalInsulin is a peptide hormone secreted in the body by beta cells of islets of Langerhans of the pancreas and regulates blood glucose levels. Medical treatment with insulin is indicated when there is inadequate production or increased insu...
Histamine Muscle Contraction Pathway
smpdb.ca/view/SMP0127055PhysiologicalHistamine activates the H1 histamine receptor on bronchiole smooth muscle myocytes. This normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) an...
Noncanonical Wnt/Ca2+ signaling
smpdb.ca/view/SMP0468891SignalingThe Wnt/Ca²⁺ pathway is activated by the binding of the Wnt ligand to a Frizzled receptor. This causes the G-protein to activate phospholipase C (PLC), which then cleaves phosphatidylinositol-4,5-bisphosphate (PIP₂) into diacylglycerol (...
Necroptosis
smpdb.ca/view/SMP0570184SignalingNecroptosis is initiated by the activation of death receptors such as TNF receptors (TNFRSF1A and TNFRSF10A) and FAS (TNFRSF6). When these receptors are activated by their ligands, they recruit FADD and activate RIPK1. RIPK1 can then eng...
Oxytocin Action Pathway
smpdb.ca/view/SMP0124714Drug actionOxytocin is a recombinant hormone used to induce or strengthen uterine contractions in pregnant women to aid in labor and delivery or to control postpartum bleeding. Administration of exogenous oxytocin is indicated in the antepartum per...
Ombitasvir Action Pathway
smpdb.ca/view/SMP0125941Drug actionOmbitasvir is a direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated end...
Daclatasvir Action Pathway
smpdb.ca/view/SMP0125943Drug actionDaclatasvir is a direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.Daclatasvir is a direct-acting antiviral agent that targets the nonstructural protein 5A ...
Velpatasvir Action Pathway
smpdb.ca/view/SMP0125945Drug actionVelpatasvir is a NS5A inhibitor used to treat chronic hepatitis C infections in patients without cirrhosis or with compensated cirrhosis, used as part of combination therapy to treat chronic Hepatitis C. Notably, velpatasvir has a signif...
Boceprevir Action Pathway
smpdb.ca/view/SMP0125956Drug actionBoceprevir is a hepatitis C virus NS3/4A protease inhibitor used in combination with other medications to treat chronic hepatitis C genotype 1 infection. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated ...
Tolterodine Action Pathway
smpdb.ca/view/SMP0126381Drug actionTolterodine is a muscarinic receptor antagonist used to treat overactive bladder with urinary incontinence, urgency, and frequency. It can be found under the brand names Detrol and Detrusitol. Tolterodine is a competitive muscarinic rece...