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Plomestane
go.drugbank.com/drugs/DB20680ExperimentalThe usage of the INN stem '-mestane' in the name indicates that Plomestane is a aromatase inhibitor. Plomestane has a monoisotopic molecular weight of 310.19 Da.
Categories: Aromatase Inhibitors, Enzyme InhibitorsPalbociclib
go.drugbank.com/drugs/DB09073ApprovedInvestigationalIt is a second generation cyclin-dependent kinase inhibitor[A176798] selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties.
Categories: BCRP/ABCG2 Inhibitors, OCT1 inhibitorsCasimiroin
go.drugbank.com/drugs/DB08744ExperimentalCasimiroin is a quinone reductase 2 inhibitor isolated from _Casimiroa edulis_.
Categories: Aromatase, Quinone Reductases, antagonists & inhibitorsTrastuzumab
go.drugbank.com/drugs/DB00072ApprovedInvestigationalProduced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth f...
Categories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitorsHesperetin
go.drugbank.com/drugs/DB01094InvestigationalHesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
Categories: BCRP/ABCG2 InhibitorsLeflutrozole
go.drugbank.com/drugs/DB19047InvestigationalLeflutrozole is under investigation in clinical trial NCT02908074 (A 6 Month Safety Extension Study of MBGS205).
Categories: Aromatase InhibitorsFadrozole
go.drugbank.com/drugs/DB16832ExperimentalCategories: Aromatase Inhibitors, Enzyme InhibitorsVorozole
go.drugbank.com/drugs/DB13767ExperimentalCategories: Aromatase Inhibitors, Enzyme InhibitorsEstrone
go.drugbank.com/drugs/DB00655ApprovedEstrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries,...
Categories: BCRP/ABCG2 Inhibitors, OATP1B1/SLCO1B1 InhibitorsTestosterone
go.drugbank.com/drugs/DB00624ApprovedInvestigationalTestosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism. Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine...
Categories: P-glycoprotein inhibitors, Thyroxine-binding globulin inhibitors