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Mitapivat
go.drugbank.com/drugs/DB16236ApprovedInvestigationalMitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells. … [A245478] On January 5, 2026, the FDA also approved the use of in the treatment of anemia in adults with alpha- or beta-thalassemia, making it the first oral treatment for this condition.[L54953]
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: Pkr-in-1Squalene
go.drugbank.com/drugs/DB11460ApprovedInvestigationalVet approvedWithdrawnSqualene is originally obtained from shark liver oil. It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. … It is ubiquitously distributed in human tissues where it is transported in serum generally in association with very low density lipoproteins. Squalene is investigated as an adjunctive cancer therapy.
Mixtures: K-OMEGASQUA (Softgel)Synonyms: (E,E,E,E)-Squalene, (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaeneEquine Botulinum Neurotoxin E Immune FAB2
go.drugbank.com/drugs/DB13897ApprovedIt is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes E in adults and pediatric patients. … Equine Botulinum Neurotoxin E Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype E.
Synonyms: Botulinum Neurotoxin E immune FAB2 (equine), BOTULINUM NEUROTOXIN E IMMUNE FAB2, EQUINETrenibotulinumtoxinE
go.drugbank.com/drugs/DB19082ApprovedInvestigationalTrenibotulinumtoxinE is a botulinum neurotoxin serotype E, produced in *Clostridium botulinum*, used for the temporary improvement in the appearance of moderate to severe glabellar lines in adults. … [L64118] It is the first and only rapid-onset, short-duration botulinum neurotoxin serotype E approved in Europe.[L64118]
Synonyms: BOTULINUM NEUROTOXIN SEROTYPE E (BONT/E) (EB-001), BONTOXILYSIN-EAllogeneic cultured keratinocytes and dermal fibroblasts in murine collagen
go.drugbank.com/drugs/DB16709Approvedmatrix proteins, all of which are known to be involved in wound repair. … [L35505] Stratagraft was in the early stages of development as far back as 2009[A237275] and was granted full FDA approval in June 2021.[L35525]
Synonyms: Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen, allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen-dsatQazCovid-in
go.drugbank.com/drugs/DB16441InvestigationalIt demonstrated high efficacy, safety, and immunogenicity at 96% in initial Phase I and II trials (NCT04530357), and will now be undergoing upcoming Phase III trials[L30633, L30638]. … The QazCovid-in vaccine, an inactivated vaccine, was developed and tested in the Kazakh Research Institute for Biological Safety Problems[L30628].
alpha-Tocopherol acetate
go.drugbank.com/drugs/DB14003ApprovedThe recommended dietary allowances (RDAs) for vitamin E alpha-tocopherol are: males = 4 mg (6 IU) females = 4 mg (6 IU) in ages 0-6 months, males = 5 mg (7.5 IU) females = 5 mg (7.5 IU) in ages 7-12 months … Vitamin E itself is naturally found in various foods, added to others, or used in commercially available products as a dietary supplement.
Mixtures: Vitamin A (100,000 Iu) and Vitamin E (20 Iu) Oral Liquid Preparation, Vitamin A (200,000 Iu) and Vitamin E (40 Iu) Oral Liquid PreparationCategories: Compounds used in a research, industrial, or household setting, Vitamin EVaricella zoster vaccine (recombinant)
go.drugbank.com/drugs/DB13924ApprovedInvestigationalfirst line therapy[L1038]. … The main immunological component of Shingrix vaccine is glycoprotein E (gE), a protein found on the surface of varicella zoster virus (VZV).
Synonyms: gE recombinant Varicella zoster virus (VZV) glycoprotein E, gE: Recombinant Varicella Zoster Virus (VZV) glycoprotein EHuman adenovirus e serotype 4 strain cl-68578 antigen
go.drugbank.com/drugs/DB14409ApprovedHuman adenovirus e serotype 4 strain cl-68578 antigen is a vaccine.
Mixtures: Adenovirus Type 4 and Type 7 Vaccine, LiveCategories: Live Human Adenovirus Type 4 VaccineE-2012
go.drugbank.com/drugs/DB05171ExperimentalE-2012 is a gamma secretase modulator that is being evaluated as a potential new treatment for Alzheimer's disease.
Categories: Heterocyclic Compounds, 1-Ring