E-2012

DB05171ExperimentalSmall molecule

E-2012 is a gamma secretase modulator that is being evaluated as a potential new treatment for Alzheimer's disease.

Mechanism: Gamma secretase plays a role in the production of beta-amyloid, a major component of plaque in the brain, which is thought to be a cause of Alzheimer's disease. E2012 is a new chemical entity discovered by Eisai and, in preclinical (laboratory) research, has shown some potential to reduce the production of beta-amyloid by modulating the function of gamma secretase.
Curator reviewed
Primary indication: Investigated for use/treatment in alzheimer's disease.Curator reviewed
Formula / weight: C₂₅H₂₆FN₃O₂ · 419.5 g/mol (avg)
Code names: E-2012

Resolves to

Compound

Structure

InChIKeyPUOAETJYKQITMO-LANLRWRYSA-NSMILES[H]\C(C1=CC(OC)=C(C=C1)N1C=NC(C)=C1)=C1\CCCN(C1=O)[C@@]([H])(C)C1=CC=C(F)C=C1

Targets

What you can answer from here — as of March 06, 2025

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with E-2012, and which of those have an active Phase 3 trial?

Create a free account or log in to explore the full data card.