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Nirmatrelvir
go.drugbank.com/drugs/DB16691ApprovedInvestigational[A234224,A234229,A234234] In 2020, Pfizer was investigating another potential treatment for SARS-CoV-2, [PF-07304814]. … Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CL<sup>PRO</sup>) inhibitor that is the subject of clinical trial NCT04756531.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesHydrocortisone
go.drugbank.com/drugs/DB00741ApprovedInvestigationalVet approvedHydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 1...
Categories: P-glycoprotein inducers, P-glycoprotein substratesProducts: K & P HYDROCORT 1 % CREME, PS-2896 Hydrocortisone Cream 1%, 0.9gPolyethylene glycol 400
go.drugbank.com/drugs/DB11077ApprovedInvestigationalPolyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. Because many PEG types are hydrophilic, they are favorably used as enhancers of penetrat...
Mixtures: Hydration PF, Systane Hydration PF Preservative FreeCategories: P-glycoprotein inhibitorsMifamurtide
go.drugbank.com/drugs/DB13615ApprovedInvestigationalAlso called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is a synthetic, less pyrogenic, and longer-acting derivative of muramyl dipeptide (MDP).
Momelotinib
go.drugbank.com/drugs/DB11763ApprovedInvestigationalMF includes primary MF (PMF), post-polycythemia vera (PV) MF, and post-essential thrombocythemia (ET) MF. Clinical manifestations of MF include anemia and thrombocytosis.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesBenzalkonium
go.drugbank.com/drugs/DB11105ApprovedInvestigationalBenzalkonium is a quaternary ammonium compound used as a biocide, a cationic surfactant, and as a phase transfer agent [FDA Label]. Benzalkonium is more commonly contained in consumer products in its salt form, benzalkonium chloride [FDA...
Mixtures: PM Toothache Relief, Orajel Instant Pain Relief Severe PMProducts: Gms Hpg Hand Sanitizer, PURELL Food Processing HEALTHY SOA P BAK E2 Antimicrobial Foam Soa pVusolimogene oderparepvec
go.drugbank.com/drugs/DB23008ApprovedInvestigational] The FDA granted vusolimogene oderparepvec-wtpg accelerated approval on August 6, 2026, in combination with nivolumab for adults with unresectable advanced cutaneous melanoma that progressed on a PD … L64062] It is the second oncolytic viral therapy approved in the United States, following talimogene laherparepvec (T-VEC, Imlygic) in 2015, and the first approved for melanoma that has progressed on anti-PD
Magnesium chloride
go.drugbank.com/drugs/DB09407ApprovedInvestigationalMagnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water.
Mixtures: Sterofundin HG 5 - Infusionslösung, Isolyte S pH 7.4Idelalisib
go.drugbank.com/drugs/DB09054ApprovedInvestigationalMore specifically, idelalisib targets P110δ, the delta isoform of the enzyme phosphatidylinositol-4,5-bisphosphate 3-kinase, also known as PI-3K. … The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesTemozolomide
go.drugbank.com/drugs/DB00853ApprovedInvestigational[A229848, A229858, L32033] Temozolomide is an imidazotetrazine prodrug that is stable at acidic pH but undergoes spontaneous nonenzymatic hydrolysis at neutral or slightly basic pH; these properties allow
Categories: P-glycoprotein substrates, P-glycoprotein substrates with a Narrow Therapeutic Index