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Cocoa butter
go.drugbank.com/drugs/DB11086ApprovedCocoa butter is an edible natural fat obtained from the _Theobroma cocoa_ seeds that is predominantly found in dark chocolate [A33033]. … Cocoa butter is included in chocolate and other food products, and can also be found in over-the-counter skin products such as lotions, creams, and bars intended to maintain skin softness.
Mixtures: Calmol 4, Preparation HProducts: Coconut Cosmetics 3-in-1 Serum, Suppo-H 1000mg/supIvacaftor
go.drugbank.com/drugs/DB08820ApprovedInvestigational, an ion channel involved in the transport of chloride and sodium ions across cell membranes. … [L6814,L6979,L6847] Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamideBevacizumab
go.drugbank.com/drugs/DB00112ApprovedInvestigational[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target. … [A192834,A192888,A192837,A192891,A192894] Bevacizumab is a humanized monoclonal IgG antibody that inhibits angiogenesis by binding and neutralizing VEGF-A.
Synonyms: 贝伐珠单抗International brands: 安倍斯, 安维汀Drotaverine
go.drugbank.com/drugs/DB06751ApprovedWithdrawnDrotaverine is an antispasmodic drug that works by inhibiting phosphodiesterase-4 (PDE4). … [A231619] It is a benzylisoquinoline derivative that is structurally related to [papaverine], although it displays more potent antispasmodic activities than papaverine.
Categories: Heterocyclic Compounds, 2-Ring, Phosphodiesterase 4 InhibitorsTafamidis
go.drugbank.com/drugs/DB11644ApprovedInvestigational[A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval on 3 May 2019.[L11280]
Categories: Heterocyclic Compounds, 2-RingSynonyms: 2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid, 6-BENZOXAZOLECARBOXYLIC ACID, 2-(3,5-DICHLOROPHENYL)-Filgrastim
go.drugbank.com/drugs/DB00099ApprovedInvestigationalIt has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in _E. Coli_. … [L40714] Human G-CSF is a glycoprotein that regulates the production and release of neutrophils from the bone marrow.
Synonyms: r-metHuG-CSFInternational brands: White-CMilrinone
go.drugbank.com/drugs/DB00235ApprovedInvestigationalOften the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and … Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population.
Categories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 3 InhibitorsSynonyms: 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrileTolvaptan
go.drugbank.com/drugs/DB06212ApprovedInvestigationalFDA approved on May 19, 2009.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexChaetomium globosum
go.drugbank.com/drugs/DB10430ApprovedChaetomium globosum is a fungus which can provoke allergic reactions. Chaetomium globosum extract is used in allergenic testing.
Mixtures: A Mold Mixture, A Mold MixtureCladosporium sphaerospermum
go.drugbank.com/drugs/DB10432ApprovedCladosporium sphaerospermum is a fungus which can provoke allergic reactions. Cladosporium sphaerospermum extract is used in allergenic testing.
Mixtures: Mold Mix 3, Mold Mix 3