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Ulipristal
go.drugbank.com/drugs/DB08867ApprovedInvestigationalUlipristal is currently recommended as first line therapy for emergency contraception, due to improved efficacy and similar side effect profile as compared to the traditional use of levonorgestrel or the … The exact mechanism of action for ulipristal is still currently debated, though there is evidence that it functions by inhibiting ovulation.
Categories: Hormonal Contraceptives for Systemic UseLasmiditan
go.drugbank.com/drugs/DB11732ApprovedInvestigational[A187316,A187322] Lasmiditan, in contrast, is a highly selective agonist of 5-HT<sub>1F</sub> receptors, carrying virtually no affinity for other receptors which appear to be largely responsible for … Their use is not devoid of concerns, however, and their vasoconstrictive activity can lead to blood pressure lability and other cardiovascular side effects - for this reason, these medications are less
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromePyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
go.drugbank.com/bio_entities/BE0000571TargetEnzymeHumansThe PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (PubMed:19081061, PubMed … The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2
Polypeptides: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialFenofibric acid
go.drugbank.com/drugs/DB13873ApprovedInvestigationalfor improved solubility, gastrointestinal absorption, and bioavailability, and more convenient administration. … It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.
Categories: Hypolipidemic Agents Indicated for Hyperlipidemia, Non-statin Hypolipidemic Agents Indicated for HyperlipidemiaCholecystokinin
go.drugbank.com/drugs/DB08862ApprovedInvestigationalWithdrawnNormally, it is an endogenous hormone but is available commercially for diagnostic processes and replacement in pancreatic insufficiency [L1646, L1647, L1648]. in the octapeptide form. … Soon after, it was recognized to be identical to the factor responsible for stimulating pancreatic exocrine secretion in 1943 [L1636].
Categories: Tests for Pancreatic FunctionFosdenopterin
go.drugbank.com/drugs/DB16628ApprovedBy improving the three-year survival rate from 55% to 84%,[L32288] and considering the lack of alternative therapies available, fosdenopterin appears poised to become a standard of therapy in the management … [A230088,A230593] In the past, management strategies for this disorder involved symptomatic and supportive treatment,[L32163] though efforts were made to develop a suitable exogenous replacement for the
Temafloxacin
go.drugbank.com/drugs/DB01405ApprovedWithdrawnIt was first approved for use in the U.S. market in 1992, but was withdrawn shortly due to the reports of serious adverse reactions, such as allergic reactions and hemolyric anemia, resulting in three … Temafloxacin is an antibiotic agent belonging to the fluoroquinolone drug class.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseMiglitol
go.drugbank.com/drugs/DB00491ApprovedUnlike other drugs of the same class, miglitol is not metabolized and the unmetabolized drug is excreted by the kidneys. … It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into
Poliovirus type 2 antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB10796ApprovedInvestigationalcaused by poliovirus Type 2. … Poliovirus type 2 antigen is a suspension of poliovirus Type 2 (MEF-1) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis
Mixtures: Polio Salk "Merieux" - Fertigspritze, Hexaxim Suspension for InjectionMethyclothiazide
go.drugbank.com/drugs/DB00232ApprovedWithdrawnA thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)