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Primidone
go.drugbank.com/drugs/DB00794ApprovedVet approvedPrimidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 Ma...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InducersMinaprine
go.drugbank.com/drugs/DB00805ApprovedMinaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant re...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesIndapamide
go.drugbank.com/drugs/DB00808ApprovedInvestigationalThe most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAcetazolamide
go.drugbank.com/drugs/DB00819ApprovedInvestigationalVet approvedOne of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizur...
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsTolazamide
go.drugbank.com/drugs/DB00839ApprovedA sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Synonyms: 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea, N-(p-Toluenesulfonyl)-N'-hexamethyleniminoureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesDonepezil
go.drugbank.com/drugs/DB00843ApprovedInvestigationalIn 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholineste...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPerphenazine
go.drugbank.com/drugs/DB00850ApprovedInvestigationalAn antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesTerbinafine
go.drugbank.com/drugs/DB00857ApprovedInvestigationalVet approvedTerbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by i...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersRanitidine
go.drugbank.com/drugs/DB00863ApprovedWithdrawnRanitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as cimetidine and famotidine. This drug helps to prevent and treat gastric-acid associated conditions, including ulc...
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsBenzphetamine
go.drugbank.com/drugs/DB00865ApprovedIllicitA sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates