Benzphetamine is a sympathomimetic used to manage exogenous obesity short term. A sympathomimetic agent with properties similar to dextroamphetamine.
- Mechanism
- Curator reviewed
The mechanism of action of these drugs is not fully understood, however it may be similar to that of amphetamines. Amphetamines stimulate noepinephrine and dopamine release in nerve endings in the lateral hypothalamic feeding centre, decreasing appetite. This release is mediated by the binding of benzphetamine to centrally located adrenergic receptors.
- Primary indication
- For the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restrictionCurator reviewed · 1 structured indication
- Formula / weight
- C17H21N · 239.3553 g/mol (avg)
- First approval
- United States, 1960
- Also known as
- (S)-benzphetamine · Benzaphetamine · Benzfetamine · Benzylamphetamine
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
YXKTVDFXDRQTKV-HNNXBMFYSA-NSMILESC[C@@H](CC1=CC=CC=C1)N(C)CC1=CC=CC=C1What you can answer from here — as of September 23, 2026
5Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Benzphetamine, and which of those have an active Phase 3 trial?
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