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Displaying results 2051 - 2060 of 2250 in total
  1. Drug

    Viltolarsen

    go.drugbank.com/drugs/DB15005
    ApprovedInvestigational

    Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function … [A218186, L15526] In this manner, PMOs are much less susceptible to endo- and exonucleases and exhibit drastically reduced metabolic degradation compared to traditional synthetic oligonucleotides.

  2. Drug

    ONO-8539

    go.drugbank.com/drugs/DB15325
    Investigational

    ONO-8539 is under investigation in clinical trial NCT01707901 (A Study of the Effect of ONO-8539 on Oesophageal Pain Hypersensitivity in Patients With Non-erosive Reflux Disease).

    Categories: Receptors, Prostaglandin E, EP1 Subtype, antagonists & inhibitors
  3. Drug

    Sonlicromanol

    go.drugbank.com/drugs/DB16333
    Investigational

    Sonlicromanol is under investigation in clinical trial NCT04165239 (The KHENERGYZE Study).

    Categories: Vitamin E, analogs & derivatives
  4. Drug

    Escherichia coli

    go.drugbank.com/drugs/DB16539
    Investigational

    Synonyms: E. ColiProducts: Symbioflor E. coli - Tropfen zum Einnehmen, Suspension
  5. Drug

    Mecbotamab vedotin

    go.drugbank.com/drugs/DB17442
    Investigational

    Mecbotamab vedotin is an anti-Axl humanized monoclonal antibody conjugated to monomethyl auristatin E using a cleavable linker (CAB-Axl-ADC).[A255212]

  6. Drug

    AMB-301

    go.drugbank.com/drugs/DB18094
    Experimental

    AMB-301 is an AAV gene therapy delivering E-selectin.[L48101] It is under investigation for the treatment of Buerger disease.

  7. Drug

    Sigvotatug Vedotin

    go.drugbank.com/drugs/DB18377
    Investigational

    Sigvotatug vedotin (SGN-B6A) is a humanized immunoglobulin G1 anti-integrin beta-6 monoclonal antibody conjugated to monomethyl auristatin E.

  8. Drug

    Nezastomig

    go.drugbank.com/drugs/DB19061
    Investigational

    Nezastomig is under investigation in clinical trial NCT06085664 (A Pilot Presurgical Trial of REGN5678 (Anti-psma X CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy

  9. Drug

    AB-207

    go.drugbank.com/drugs/DB22801
    Investigational

    AB-207 is under investigation in clinical trial NCT06456073 (E-CEL UVEC Treatment for Anal Fissures).

    Synonyms: E-CEL UVE, E-CEL UVEC cells
  10. Drug

    Idursulfase

    go.drugbank.com/drugs/DB01271
    ApprovedInvestigational

    The enzyme contains eight asparagine-linked glycosylation sites occupied by complex oligosaccharide structures.