Search

Displaying results 2051 - 2060 of 8696 in total
  1. Drug

    Fidaxomicin

    go.drugbank.com/drugs/DB08874
    ApprovedInvestigational

    [A190516] The FDA initially approved fidaxomicin in May 2011 for the treatment of _C. difficile_-associated diarrhea in adult patients over the age of 18. … [A190486] The minimum inhibitory concentration (MIC<sub>90</sub>) for fidaxomicin is four times less than that of [vancomycin], which was the primary drug of choice for _C. difficile_ infection before

    Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A Inhibitors
  2. Drug

    Alvespimycin

    go.drugbank.com/drugs/DB12442
    Investigational

    It has been used in trials studying the treatment of solid tumor in various cancer as an antitumor agent.

  3. Drug

    Tioconazole

    go.drugbank.com/drugs/DB01007
    Approved

    Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. … Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus".

    Categories: Antifungals for Topical Use, Antifungals for Dermatological Use
  4. Drug

    Damoctocog alfa pegol

    go.drugbank.com/drugs/DB14700
    ApprovedInvestigational

    In recent years, various extended half-life factor VIII and factor IX preparations have been studied and gained approval.

  5. Drug

    Tannic acid

    go.drugbank.com/drugs/DB09372
    ApprovedInvestigational

    Nowadays, tannic acid is applied topically for the treatment of cold sores, diaper rash, fever blisters and poison ivy. … Tannic acid is also taken by mouth and applied directly for bleeding, chronic diarrhea, dysentery, bloody urine, painful joints, persistent coughs, and cancer.

    Mixtures: Germa Tan
  6. Drug

    Canfosfamide

    go.drugbank.com/drugs/DB04972
    Investigational

    Canfosfamide is an active agent in chemotherapy-resistant ovarian cancer.

  7. Drug

    Pyrimethamine

    go.drugbank.com/drugs/DB00205
    ApprovedInvestigationalVet approved

    One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.

    Mixtures: Rhobazin Plus Solution for Oral UseCategories: Antibiotics for Pneumocystis Pneumonia, Cytochrome P-450 CYP2C8 Inhibitors
  8. Drug

    Pizotifen

    go.drugbank.com/drugs/DB06153
    Approved

    [A32532] It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. … Pizotifen hydrochloride is an active ingredient in Sandomigran, which is used for the prophylactic management of migraines.

    Categories: Adrenergic alpha-1 Receptor Antagonists, Serotonin Receptor Antagonists
  9. Drug

    Technetium Tc-99m oxidronate

    go.drugbank.com/drugs/DB09139
    ApprovedWithdrawn

    [L1137] The radiopharmaceuticals based on technetium-99m are widely used for diagnostic purposes because 99mTc has a versatile chemistry which allows it to produce an extense variety of complexes with … [L1138] These complexes are formed by the binding of 99mTc to metal atoms of an organic molecule.

  10. Drug

    Safinamide

    go.drugbank.com/drugs/DB06654
    ApprovedInvestigational

    Safinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.

    Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Cytochrome P-450 Substrates