Identification
- Generic Name
- Tannic acid
- DrugBank Accession Number
- DB09372
- Background
Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. It acts as a weak acid. Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine. In the old days it was used as antidote against different poisons. Nowadays, tannic acid is applied topically for the treatment of cold sores, diaper rash, fever blisters and poison ivy. Tannic acid is also taken by mouth and applied directly for bleeding, chronic diarrhea, dysentery, bloody urine, painful joints, persistent coughs, and cancer.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Tannic acid (DB09372)
- Weight
- Average: 1701.206
Monoisotopic: 1700.172974194 - Chemical Formula
- C76H52O46
- Synonyms
- ácido tánico
- Gallotannic acid
- Gallotannin
- Tannic acid
Pharmacology
- Indication
Tannic acid is indicated for cold sores, fever blisters, diaper rash, minor burn or sunburn and prickly heat. Vaginally, tannic acid is used as a douche for leukorrhea. It has been also indicated for sore throat, inflamed tonsils, spongy or receding gums, and acute dermatitis.
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Not Available
- Mechanism of action
Pharmaceutical grade tannic acid is generally considered to be pentadigalloylglucose. It has an astringent effect. When used internally, it dehydrates tissues when cause reduction in secretions. Externally, it works through formation of protective layer of harder and constricted cells. Tannic acid is thought to exert antiviral and antibacterial effects.
- Absorption
After ingestion it has poor bioavailability, due to large size, high affinity to bound to plasma proteins and low lipid solubility. Its main actions are due to local effects.
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
Orally administered Tannic acid is hydrolysable tannin which releases gallic acid and other compounds upon decomposition.
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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LD50 is 2.26 g/Kg in rats.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Zilactin Medicated Gel 7% Gel 7 % Topical Zila, Inc. 1991-12-31 1996-09-09 Canada 
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 4Jointz Tannic acid (5 g/100g) + Allantoin (0.025 g/100g) + Eucalyptus oil (4 g/100g) Cream Topical Arp(usa) Pty Ltd 2017-01-31 2018-04-05 US 
Blood Stop Liq Tannic acid (62.2 mg / mL) + Potassium alum (62.2 mg / mL) Liquid Topical Laboratoire Romilo 1979-12-31 1999-08-18 Canada Extrait De Fraises Tannic acid (1.3 g / 100 mL) + Strawberry (2.5 mL / 100 mL) Liquid Oral Produits Marc O (1987) Inc., Division Of Technilab Inc. 1980-04-02 2000-08-24 Canada Germa Tan Tannic acid (.4 %) + Triclosan (.01 %) Aerosol Topical Mueller Sports Medicine, Inc. 1970-12-31 2002-07-15 Canada Nitrotan Tannic acid (0.015 g/1g) + Benzyl alcohol (0.061 g/1g) + Isopropyl alcohol (0.62 g/1g) + Picric acid (0.002 g/1g) Aerosol, spray Topical Cramer Products, Inc 1992-07-15 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 28F9E0DJY6
- CAS number
- 1401-55-4
- InChI Key
- LRBQNJMCXXYXIU-YIILYMKVSA-N
- InChI
- InChI=1S/C76H52O46/c77-32-1-22(2-33(78)53(32)92)67(103)113-47-16-27(11-42(87)58(47)97)66(102)112-21-52-63(119-72(108)28-12-43(88)59(98)48(17-28)114-68(104)23-3-34(79)54(93)35(80)4-23)64(120-73(109)29-13-44(89)60(99)49(18-29)115-69(105)24-5-36(81)55(94)37(82)6-24)65(121-74(110)30-14-45(90)61(100)50(19-30)116-70(106)25-7-38(83)56(95)39(84)8-25)76(118-52)122-75(111)31-15-46(91)62(101)51(20-31)117-71(107)26-9-40(85)57(96)41(86)10-26/h1-20,52,63-65,76-101H,21H2/t52-,63-,64+,65-,76?/m1/s1
- IUPAC Name
- (2R,3R,4S,5R)-4,5,6-tris[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]-2-{[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]methyl}oxan-3-yl 3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoate
- SMILES
- OC1=CC(=CC(O)=C1O)C(=O)OC1=C(O)C(O)=CC(=C1)C(=O)OC[C@H]1OC(OC(=O)C2=CC(OC(=O)C3=CC(O)=C(O)C(O)=C3)=C(O)C(O)=C2)[C@H](OC(=O)C2=CC(OC(=O)C3=CC(O)=C(O)C(O)=C3)=C(O)C(O)=C2)[C@@H](OC(=O)C2=CC(OC(=O)C3=CC(O)=C(O)C(O)=C3)=C(O)C(O)=C2)[C@@H]1OC(=O)C1=CC(OC(=O)C2=CC(O)=C(O)C(O)=C2)=C(O)C(O)=C1
References
- General References
- External Links
- PubChem Substance
- 347910448
- ChemSpider
- 17288010
- 10328
- ChEBI
- 75211
- Wikipedia
- Tannic_acid
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Abdominal Pain / Dyspepsia / Gastro-esophageal Reflux Disease (GERD) / Intestinal Malabsorption 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Cream Topical Liquid Oral Aerosol Topical Ointment Nasal Aerosol, spray Topical Tablet Oral Liquid Topical Gel Topical 7 % Powder Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.407 mg/mL ALOGPS logP 4.73 ALOGPS logP 13.51 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 7.61 Chemaxon pKa (Strongest Basic) -4.8 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 36 Chemaxon Hydrogen Donor Count 25 Chemaxon Polar Surface Area 777.98 Å2 Chemaxon Rotatable Bond Count 31 Chemaxon Refractivity 393.57 m3·mol-1 Chemaxon Polarizability 152.88 Å3 Chemaxon Number of Rings 11 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at November 30, 2015 19:10 / Updated at February 21, 2021 18:52