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Oseltamivir
go.drugbank.com/drugs/DB00198ApprovedInvestigationalOseltamivir exerts its antiviral activity by inhibiting the activity of the viral neuraminidase enzyme found on the surface of the virus, which prevents budding from the host cell, viral replication, and … to outweigh the small clinical benefit of use of oseltamivir.
Quinidine
go.drugbank.com/drugs/DB00908Approved[A38016] Due to its side effects and increased risk of mortality, the use of quinidine was reduced over the next few decades. … Quinidine is a D-isomer of [quinine] present in the bark of the Cinchona tree and similar plant species.
Categories: Adrenergic alpha-1 Receptor AntagonistsErtapenem
go.drugbank.com/drugs/DB00303ApprovedInvestigational[A447] Shown to be effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria, ertapenem is used to treat various bacterial infections. … Ertapenem is a 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics.[L14339] It was first authorized for use in the US in November 2001 and in Europe in April 2002.
Potassium hydroxide
go.drugbank.com/drugs/DB11153ApprovedIt was determined that topical KOH solution was found to be a safe and effective treatment of plane warts [L1941]. … Potassium hydroxide is also a precursor to other potassium compounds. Potassium hydroxide is used in food to adjust pH, as a stabilizer, and as a thickening agent.
Synonyms: hydroxyde de potassiumClorazepic acid
go.drugbank.com/drugs/DB00628ApprovedIllicitSimilar to other benzodiazepines, the active metabolite of clorazepate enhances the binding of gamma-aminobutyric acid (GABA) to the GABA type A (GABA-A) receptor, which promotes channel opening and neuronal … Also, the use of clorazepate exposes users to users to the risks of abuse, misuse, and addiction, and its continued use may lead to significant physical dependence.
Products: Tranxene T-Tab, Clorazepate Dipotassium T-TabCarbinoxamine
go.drugbank.com/drugs/DB00748ApprovedThis antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. … The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many
Procarbazine
go.drugbank.com/drugs/DB01168ApprovedInvestigationalAn antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeLanreotide
go.drugbank.com/drugs/DB06791ApprovedInvestigationalIt is approved in several countries worldwide, including the United Kingdom, Australia, and Canada. Lanreotide was first approved for use in the United States by the FDA on August 30, 2007. … Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome
Categories: Somatostatin Receptor AgonistsTebentafusp
go.drugbank.com/drugs/DB15283ApprovedInvestigationalto be approved by the FDA. … This approval marks the first bispecific T cell engager to be approved by the FDA to treat a solid tumour and being the first and only therapy for the treatment of unresectable or metastatic uveal melanoma
Categories: Bispecific gp100 Peptide-HLA-directed CD3 T Cell EngagerLeflunomide
go.drugbank.com/drugs/DB01097ApprovedInvestigationalLeflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous.