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Tyrosine-protein kinase transmembrane receptor ROR2
go.drugbank.com/bio_entities/BE0010827TargetHumansMay act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443) … Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity).
Polypeptides: Tyrosine-protein kinase transmembrane receptor ROR2Synonyms: Neurotrophic tyrosine kinase, receptor-related 2Killer cell immunoglobulin-like receptor 2DL2
go.drugbank.com/bio_entities/BE0010848TargetHumansReceptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis
Polypeptides: Killer cell immunoglobulin-like receptor 2DL2Synonyms: p58 NK receptor CL-43, p58 natural killer cell receptor clone CL-43Killer cell immunoglobulin-like receptor 3DL2
go.drugbank.com/bio_entities/BE0010849TargetHumansReceptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). … Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464)
Polypeptides: Killer cell immunoglobulin-like receptor 3DL2Synonyms: p70 NK receptor CL-5, p70 natural killer cell receptor clone CL-5Interleukin-22 receptor subunit alpha-1
go.drugbank.com/bio_entities/BE0016650TargetHumansComponent of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. … Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation.
Polypeptides: Interleukin-22 receptor subunit alpha-1Synonyms: IL-22 receptor subunit alpha-1, Cytokine receptor class-II member 9Taste receptor type 2 member 3
go.drugbank.com/bio_entities/BE0023234TargetHumansGustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5
Polypeptides: Taste receptor type 2 member 3Function: bitter taste receptor activityT cell receptor beta variable 13
go.drugbank.com/bio_entities/BE0023663TargetHumansV region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).
Polypeptides: T cell receptor beta variable 13T cell receptor delta variable 2
go.drugbank.com/bio_entities/BE0023749TargetHumansV region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447).
Polypeptides: T cell receptor delta variable 2Tofacitinib
go.drugbank.com/drugs/DB08895ApprovedInvestigationalTofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. … It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate.
Inulin
go.drugbank.com/drugs/DB00638ApprovedInvestigationalNutraceuticalA starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan. … It has been used in physiologic investigation for determination of the rate of glomerular function.
Categories: Compounds used in a research, industrial, or household settingTislelizumab
go.drugbank.com/drugs/DB14922ApprovedInvestigational[L50346] It has subsequently been approved for additional cancers in the US and EU. [L49349] … Tislelizumab is a humanized monoclonal IgG4 antibody against programmed death receptor-1 (PD-1).
Categories: Programmed Death Receptor-1 Blocking Antibody