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Sirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigational[L39267] Sirolimus was also investigated in other cancers such as skin cancer, Kaposi’s Sarcoma, cutaneous T-cell lymphomas, and tuberous sclerosis. … Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: RAPAMUNE 1 MG FILM DRAJE, 30 ADET, RAPAMUNE 1 MG 100 FILM DRAJEInsulin human
go.drugbank.com/drugs/DB00030ApprovedInvestigationalMarketed as the brand name product Humulin R or Novolin R, human insulin begins to exert its effects within 30 minutes of subcutaneous administration, while peak levels occur 3-4 hours after administration … NPH insulin is provided as a crystalline suspension of insulin with protamine and zinc, resulting in an onset of action in 1 to 3 hours, duration of action up to 24 hours, and peak action from 6 to 8 hours
Mixtures: MIXTARD 30 HM PENFİLL 100 IU/ML ENJEKSİYONLUK SÜSPANSİYON İÇEREN KARTUŞ, 5 ADET, MIXTARD 30 HM PENFİLL 100 IU/ML ENJEKSİYONLUK SÜSPANSİYON İÇEREN KARTUŞ, 5 ADETCategories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersCetuximab
go.drugbank.com/drugs/DB00002ApprovedInvestigational[A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis. … Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor
Products: ERBITUX ® 5 MG/ML, ERBITUX® 5 MG/MLFondaparinux
go.drugbank.com/drugs/DB00569ApprovedInvestigationalFondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. … Fondaparinux potentiates the neutralizing action of ATIII on activated Factor X 300-fold.
Products: ARIXTRA ® 7.5 MG /0.6 ML, ARIXTRA 7.5 MG/0.6 ML S.C. ENJEKSIYONLUK COZELTI ICEREN KULLANIMA HAZIR SIRINGA, 10 ADETDimenhydrinate
go.drugbank.com/drugs/DB00985ApprovedInvestigational[L32980,L32985,L32995] Dimenhydrinate is a combination of [Diphenhydramine] and [8-chlorotheophylline] in a salt form, with 53%-55.5% dried diphenhydramine, and 44%-47% died 8-chlorotheophylline. … Dimehydrinate was first described in the literature in 1949,[A233120] and patented in 1950.
Synonyms: 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1), N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinateInternational brands: Vomex ADexmedetomidine
go.drugbank.com/drugs/DB00633ApprovedInvestigationalVet approvedAn agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.
Synonyms: (+)-4-((S)-α,2,3-trimethylbenzyl)imidazole, (+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazoleCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsNaproxen
go.drugbank.com/drugs/DB00788ApprovedInvestigationalVet approved[A179098] Given its overall tolerability and effectiveness, naproxen can be considered a first line treatment for a variety of clinical situations requiring analgesia. … [A178975] It can effectively manage acute pain as well as pain related to rheumatic diseases, and has a well studied adverse effect profile.
Synonyms: (+)-(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid, (S)-2-(6-Methoxy-2-naphthyl)propanoic acidInternational brands: Bumaflex N, Proxen SLisinopril
go.drugbank.com/drugs/DB00722ApprovedInvestigational[A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.
Mixtures: AMLIPIN 5 / 10 MG FILM TABLET, 30 ADET, AMLIPIN 5 / 5 MG FILM TABLET, 30 ADETCategories: Compounds used in a research, industrial, or household settingZoledronic acid
go.drugbank.com/drugs/DB00399ApprovedInvestigationalZoledronic acid, or CGP 42'446,[A203120] is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid].
Salts: Zoledronate D,L-Lysine MonohydrateCategories: Heterocyclic Compounds, 1-RingAstemizole
go.drugbank.com/drugs/DB00637ApprovedWithdrawnAstemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms.
Synonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole, 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazoleCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates