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Lubiprostone
go.drugbank.com/drugs/DB01046ApprovedInvestigationalA prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. … Activation of these channels promotes the secretion of a chloride-rich fluid that soften the stool, increase gastrointestinal motility, and induce spontaneous bowel movements (SBM).
Tivozanib
go.drugbank.com/drugs/DB11800ApprovedInvestigationalRenal cell carcinoma (RCC) is responsible for 3% of cancer cases[A231314] and is one of the 10 most common cancers in adults. The average age of diagnosis is between age 65 to 74. … [L32529] Tivozanib, also known as FOTIVDA, is a kinase inhibitor developed to treat adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) after prior failed systemic therapies
Andexanet alfa
go.drugbank.com/drugs/DB14562ApprovedIt is marketed as Andexxa for intravenous injection or infusion and is indicated for the reversal of anticoagulation in combination with [rivaroxaban] and [apixaban] in cases of life-threatening or uncontrolled … However, the use of these agents is associated with a risk for uncontrollable bleeding episodes that can lead to can cause serious or fatal bleeding.
Guanethidine
go.drugbank.com/drugs/DB01170ApprovedWithdrawnIt is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Hydroxychloroquine
go.drugbank.com/drugs/DB01611ApprovedInvestigational[A192132] **The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020. … [A183092] Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2.
Products: Nu-hydroxyquine, ARTROQUIN 400 MGCobamamide
go.drugbank.com/drugs/DB11191ApprovedNutraceuticalCobamamide is one of the active forms of vitamin B12 that is also known as _adenosylcobalamin_ or _dibencozide_. … It is therefore important to treat vitamin B12 deficiency with a combination of MeCbl and AdCbl or hydroxocobalamin or cobalamin [L2054].
Categories: Heterocyclic Compounds with 4 or More RingsApixaban
go.drugbank.com/drugs/DB06605ApprovedInvestigationalApixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic … Apixaban was approved by the FDA on December 28, 2012[L6043].
Products: ELIQUIS® 5 MG, Ag-apixabanCimetidine
go.drugbank.com/drugs/DB00501ApprovedInvestigationalIt also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. … Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output.
Categories: Metabolic Side Effects of Drugs and SubstancesProducts: Nu-cimet Tab 600mg, Nu-cimet Tab 400mgInavolisib
go.drugbank.com/drugs/DB15275ApprovedInvestigationalInavolisib is an inhibitor of PI3Kα that was approved by the FDA in October 2024 for the treatment of certain patients with advanced breast cancers. … _PIK3CA_ is one of the most frequently mutated oncogenes, with the resulting mutated p110α protein it encodes playing a central role in tumor cell proliferation.
Afatinib
go.drugbank.com/drugs/DB08916ApprovedInvestigationalAfatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label].
Products: GIOTRIF® 30 MG, GIOTRIF® 40 MG