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Benzylparaben
go.drugbank.com/drugs/DB14176ApprovedBenzylparaben is used in allergenic testing.
Synonyms: Benzyl 4-hydroxybenzoate, Benzyl p-hydroxybenzoateDiroximel fumarate
go.drugbank.com/drugs/DB14783ApprovedInvestigational[A187535] Diroximel fumarate is a new drug from the fumarate class formulated to treat various relapsing forms of MS. … Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life.
Vosoritide
go.drugbank.com/drugs/DB11928ApprovedInvestigationalVosoritide is an analog of CNP with proline-glycine on its N-terminus to convey resistance to neutral endopeptidase. … Achondroplasia is an autosomal dominant genetic disease and the most common cause of dwarfism in humans.
Categories: C-type Natriuretic Peptide AnalogVoclosporin
go.drugbank.com/drugs/DB11693ApprovedInvestigationalLN is a significant cause of renal failure, morbidity, and death in patients with SLE. … Lupus nephritis (LN) is a type of glomerulonephritis occurring in patients with systemic lupus erythematosus (SLE).
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesThymidine
go.drugbank.com/drugs/DB04485ApprovedInvestigationalThymidine is a naturally occurring deoxyribonucleoside that is a crucial component of the DNA salvage pathway and a building block for DNA synthesis. … [A274683, A274688] As of now, its primary role is in research and as a sensitizer or modulator in experimental chemotherapy regimens, rather than a standalone, approved therapeutic agent.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-(2-Deoxy-?-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione, 1-(2-DEOXY-.BETA.-D-ERYTHRO-PENTOFURANOSYL)-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONEAntithrombin III human
go.drugbank.com/drugs/DB11598ApprovedInvestigationalA plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Synonyms: Heparin cofactor BProducts: KYBERNIN P, KYBERNIN P 500Taletrectinib
go.drugbank.com/drugs/DB18711ApprovedInvestigational[L53308] Gene fusions involving _ROS1_, a proto-oncogene, have been identified as oncogenic drivers in 1-2% of patients with non-small cell lung cancer (NSCLC), in addition to other cancers at variable … Taletrectinib is an orally available small molecule kinase inhibitor.
Categories: MATE 1 Substrates, MATE 2 InhibitorsSotagliflozin
go.drugbank.com/drugs/DB12713ApprovedInvestigationalSotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind,[A244499] which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type … 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m<sup>2</sup>.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesMethacholine
go.drugbank.com/drugs/DB06709Approved[A229598, A229603] Although the underlying pathology of AHR is complex, ASM contraction can be stimulated by cholinergic agonists that activate M<sub>3</sub> muscarinic receptors that stimulate ASM contraction … [A229648, L31763] Methacholine was granted FDA approval on October 31, 1986, and is marketed under the trademark PROVOCHOLINE® by Methapharm Inc.[L31763]
Ubrogepant
go.drugbank.com/drugs/DB15328ApprovedInvestigationalUbrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. … [L10926] It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine.
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates