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Metreleptin
go.drugbank.com/drugs/DB09046ApprovedInvestigationalMetreleptin is produced in _E. coli_ and differs from native human leptin by the addition of a methionine residue at its amino terminus. … Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy.
Synonyms: r-metHuLeptin, N-MethionylleptinPoractant alfa
go.drugbank.com/drugs/DB09113ApprovedInvestigationaland SP-C). … Poractant alfa is an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids) and 1% hydrophobic low molecular weight proteins (surfactant associated proteins SP-B
Products: CUROSURF ® 3.0 ML, CUROSURF 240 MG/3 ML INTRATRAKEAL SUSPANSIYON IÇEREN FLAKON, 1 ADETCoagulation factor XIa
go.drugbank.com/drugs/DB15420InvestigationalCoagulation factor XIa is under investigation in clinical trial NCT01701947 (HEMOLEVEN® Expanded Access Program Prevention of Surgical/Postpartum Hemorrhage Severe Inherited Factor XI Deficiency).
Categories: Factor XISynonyms: Human coagulation factor XIFerric pyrophosphate citrate
go.drugbank.com/drugs/DB13995ApprovedFerric pyrophosphate citrate is a soluble iron replacement product. … The ferric ion is strongly complexed by pyrophosphate and citrate.[A31979] FPC is categorized in Japan as a second class OTC drug.
Levamlodipine
go.drugbank.com/drugs/DB09237ApprovedInvestigational[L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity. … Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication.
Mixtures: ALENCAL IRBE 5/300MG TABLETAS RECUBIERTAS, ALENCAL VALS 5/320 MG TABLETAS RECUBIERTASCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesParoxetine
go.drugbank.com/drugs/DB00715ApprovedInvestigationalParoxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. … [L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters.
Synonyms: (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine, (−)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidineCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesCalcium levulinate
go.drugbank.com/drugs/DB13800ApprovedThe relatively new calcium levulinate is produced from a direct reaction between L- or levulinic acid levulose and calcium hydroxide [L2765]. … This formulation is considered a low molecular weight organic calcium ion type that is easily absorbed through the intestinal wall [L2765].
Mixtures: CALCIUM PICKEN %10 ENJEKSİYONLUK ÇÖZELTİ AMPUL, 5 ADET, CALCİLES 225 MG+572 MG/10 ML ENJEKSİYONLUK ÇÖZELTİ, 5 ADETSelumetinib
go.drugbank.com/drugs/DB11689ApprovedInvestigationalNF-1 is considered rare, with an estimated incidence of 1/3000 individuals. … [A193611] However, selumetinib demonstrated impressive efficacy and tolerability in Phase I trials, leading to its continued investigation for the treatment of various types of tumours in Phase II trials
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesUbrogepant
go.drugbank.com/drugs/DB15328ApprovedInvestigationalUbrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. … [L10926] It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesAgkistrodon piscivorus antivenin
go.drugbank.com/drugs/DB13894ApprovedThe cottonmouth, Agkistrodon piscivorus, is a large, venomous snake in the pit viper subfamily (Crotalinae). … This species of snake is endemic to the United States.