Ferric pyrophosphate citrate is a soluble iron compound used to maintain hemoglobin levels in patients undergoing hemodialysis. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma.
- Mechanism
- Curator reviewed · 1 reference
The usage of ferric pyrophosphate is based on the strong complex formation between these two species. Besides, the capacity of pyrophosphate to trigger iron removal from transferrin, enhance iron transfer from transferrin to ferritin and promote iron exchange between transferrin molecules. These properties make it a very suitable compound for parenteral administration, iron delivery into circulation and incorporation into hemoglobin.
- Primary indication
- Ferric pyrophosphate citrate is indicated for the treatment of iron loss or iron deficiency to maintain hemoglobin and to reduce the prescribed dose of erythropoiesis-stimulating agent (ESA) required to maintain desired hemoglobin levels.Curator reviewed · 1 structured indication
- Formula / weight
- C18H24Fe4O42P6 · 1321.571 g/mol (avg)
- First approval
- Canada, 2021 · United States, 2015
- Also known as
- Tetraferric nonahydrogen citrate pyrophosphate · Triferic
- Code names
- H-61
- Brand names
Resolves to
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Which drugs share a target with Ferric pyrophosphate citrate, and which of those have an active Phase 3 trial?
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